Ninomiya K, Ohbayashi F, Hasegawa Y
Jpn J Antibiot. 1985 Dec;38(12):3629-33.
Antimicrobial activity of aztreonam (AZT) against 231 clinical isolates in the field of obstetrics and gynecology was determined by agar-plates dilution method. Almost of all strains of E. coli (108 strains) tested were susceptible to the concentration of 0.20 micrograms/ml of AZT. Anaerobic bacteria, however, were less susceptible to this antibiotic than to cefazolin. The concentrations of AZT were determined in serum and pelvic tissue samples obtained at various intervals after 1 hour intravenous drip infusion with 1 g. The concentrations of AZT in pelvic tissues were maximal 9.3 micrograms/g at 57 minutes but less than 0.6 micrograms/g at 3 hours or more after injection. Clinical efficacy of AZT was evaluated in 6 cases consisted of two each with Bartholin's abscess and intrauterine infection and one each with post partum endometritis and acute adnexitis. Clinical efficacies were seen in 5 cases.
采用琼脂平板稀释法测定了氨曲南（AZT）对231株妇产科临床分离菌株的抗菌活性。几乎所有检测的大肠杆菌菌株（108株）对0.20微克/毫升浓度的AZT敏感。然而，厌氧菌对这种抗生素的敏感性低于头孢唑林。在静脉滴注1克AZT 1小时后，于不同时间间隔采集血清和盆腔组织样本，测定其中AZT的浓度。盆腔组织中AZT的浓度在57分钟时最高，为9.3微克/克，但在注射后3小时及更长时间时低于0.6微克/克。对6例患者进行了AZT临床疗效评估，其中巴氏腺脓肿、子宫内感染各2例，产后子宫内膜炎和急性附件炎各1例。5例患者有临床疗效。
