Krannert Institute of Cardiology, Indiana University School of Medicine, 1801 Senate Blvd Suite 2000, Indianapolis, IN, 46202, USA.
Heart Fail Rev. 2024 May;29(3):707-711. doi: 10.1007/s10741-024-10391-0. Epub 2024 Feb 11.
The worldwide experience with mechanical circulatory support in adult patients with single ventricle and Fontan palliation is limited. We aimed to see the outcomes in such patients on durable left ventricular assist device. We systematically reviewed the English language literature found on PubMed and Google Scholar, searching the terms "Fontan," "single ventricle," "ventricular assist device," "LVAD," and "mechanical circulatory support," and selected all individual cases with reported outcomes. We identified 4 patients on pulsatile left ventricular assist device, all of whom were successfully bridged to transplant, and 15 patients on continuous flow LVAD, age 25.9 ± 5.8, predominantly males. Mean time on LVAD support was 718.6 ± 616.5 days, and only 2 patients (13.3%) died. Durable left ventricular assist device support in adult patients with Fontan provides excellent results and should be used more frequently.
全世界在接受机械循环支持的成人单心室和 Fontan 姑息治疗患者中的经验有限。我们旨在观察此类患者在耐用性左心室辅助装置上的结果。我们系统地审查了在 PubMed 和 Google Scholar 上发现的英文文献，使用了“Fontan”、“单心室”、“心室辅助装置”、“LVAD”和“机械循环支持”等术语，并选择了所有报告结果的个别病例。我们确定了 4 例接受搏动性左心室辅助装置治疗的患者，所有患者均成功过渡到移植，15 例接受连续流 LVAD 治疗，年龄为 25.9±5.8 岁，主要为男性。LVAD 支持的平均时间为 718.6±616.5 天，只有 2 名患者（13.3%）死亡。在 Fontan 的成人患者中使用耐用性左心室辅助装置可获得极佳的效果，应更频繁地使用。
