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A型肉毒毒素在疝修补术前腹壁肌肉康复中的应用:共识建议。

Use of botulinum toxin type A in the prehabilitation of abdominal wall musculature for hernia repair: a consensus proposal.

机构信息

Unidad de Cirugía de Pared y Corta Estancia, Hospital Universitario y Politécnico La Fe, Valencia, España.

Unidad de Cirugía de Pared y Corta Estancia, Hospital Universitario y Politécnico La Fe, Valencia, España.

出版信息

Cir Esp (Engl Ed). 2024 Jul;102(7):391-399. doi: 10.1016/j.cireng.2023.12.003. Epub 2024 Feb 9.

DOI:10.1016/j.cireng.2023.12.003
PMID:38342140
Abstract

The prehabilitation of the abdominal wall through the infiltration of botulinum toxin type A, which induces temporary chemical denervation ("chemical component separation") in the lateral abdominal musculature, is a common practice in units specialized in abdominal wall surgery. However, its use for this indication is currently off-label. The main objective of this article is to describe a consensus proposal regarding indications, contraindications, dosages employed, potential side effects, administration method, and measurement of possible outcomes. Additionally, a proposal for an informed consent document endorsed by the Abdominal Wall Section of the Spanish Association of Surgeons is attached.

摘要

腹壁的预康复通过注射肉毒毒素 A,在侧腹肌中诱导暂时的化学去神经支配(“化学性成分分离”),这在专门从事腹壁手术的单位中是一种常见做法。然而,目前其在该适应证中的应用是超适应证的。本文的主要目的是描述关于适应证、禁忌证、使用剂量、潜在副作用、给药方法和可能结果的测量的共识建议。此外,还附有西班牙外科医生协会腹壁分会认可的知情同意书草案。

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引用本文的文献

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Effectiveness of pre-operative chemical component separation with computed tomography-guided intramuscular injection of OnabotulinumtoxinA in outcomes of large complex incisional ventral abdominal hernia repair: a propensity score-weighted comparative analysis.计算机断层扫描引导下肌内注射奥曲肽毒素A进行术前化学成分分离对大型复杂切口疝修补术结局的有效性:倾向评分加权比较分析
Hernia. 2025 May 23;29(1):171. doi: 10.1007/s10029-025-03369-w.
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Does sarcopenia have a negative impact on the efficacy of botulinum toxin A in the prehabilitation of patients undergoing incisional hernia repair? A multicentric retrospective study.肌肉减少症对接受切口疝修补术患者术前康复中A型肉毒毒素的疗效有负面影响吗?一项多中心回顾性研究。
Hernia. 2025 Feb 18;29(1):104. doi: 10.1007/s10029-025-03291-1.
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Iatrogenic Botulism Following Botulinum Toxin Injection as an Adjunct to Abdominal Wall Reconstruction for Incisional Hernia.肉毒杆菌毒素注射作为切口疝腹壁重建辅助治疗后的医源性肉毒中毒
Cureus. 2024 Nov 15;16(11):e73773. doi: 10.7759/cureus.73773. eCollection 2024 Nov.