Qin Jiaxuan, Duan Bo, Chen Bowen, Xing Jinchun, Wang Tao
Department of Urology Surgery, The First Affiliated Hospital of Xiamen University, Fujian, China.
J Coll Physicians Surg Pak. 2024 Feb;34(2):206-211. doi: 10.29271/jcpsp.2024.02.206.
Former studies have suggested that urolithiasis is related to Klotho gene polymorphisms. The aim of this meta-analysis was to investigate this relationship. Studies on the association between urolithiasis susceptibility and Klotho gene polymorphisms were systematically searched for in databases. Odds ratios and 95% confidence intervals were pooled as the effect size. This meta-analysis incorporated ten articles. Klotho rs1207568 adenine (A) may be related to a decreased urolithiasis risk in Caucasians. The results showed that Klotho rs3752472 may not be related to urolithiasis risk in the Han Asian subgroup. Klotho rs564481 may not be related to urolithiasis risk in Asians or Caucasians, and Klotho rs650439 may not be related to urolithiasis risk in Asians. Key Words: Klotho, Single-nucleotide polymorphism, Urolithiasis, Meta-analysis.
既往研究表明，尿石症与Klotho基因多态性有关。本荟萃分析的目的是研究这种关系。在数据库中系统检索了关于尿石症易感性与Klotho基因多态性之间关联的研究。汇总比值比和95%置信区间作为效应量。本荟萃分析纳入了10篇文章。Klotho rs1207568腺嘌呤（A）可能与白种人尿石症风险降低有关。结果显示，Klotho rs3752472可能与亚洲汉族亚组的尿石症风险无关。Klotho rs564481可能与亚洲人或白种人的尿石症风险无关，而Klotho rs650439可能与亚洲人的尿石症风险无关。关键词：Klotho、单核苷酸多态性、尿石症、荟萃分析。
