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DNA Damage and Cellular Senescence in Osteoarthritis: An Unexpected Role for Interferon Regulatory Factor 1 in Chondrocyte DNA Repair.

作者信息

Diekman Brian O, Loeser Richard F

机构信息

University of North Carolina, Chapel Hill, and North Carolina State University, Raleigh.

University of North Carolina School of Medicine, Chapel Hill.

出版信息

Arthritis Rheumatol. 2024 Jun;76(6):842-844. doi: 10.1002/art.42822. Epub 2024 Feb 27.

DOI:10.1002/art.42822
PMID:38343350
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11136596/
Abstract
摘要

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引用本文的文献

[1]
Cellular Senescence in Human Chondrocytes in Relation to Osteoarthritis.

Cartilage. 2025-6-16

本文引用的文献

[1]
Predisposal of Interferon Regulatory Factor 1 Deficiency to Accumulate DNA Damage and Promote Osteoarthritis Development in Cartilage.

Arthritis Rheumatol. 2024-6

[2]
Sirtuin 6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes.

Aging (Albany NY). 2023-12-9

[3]
An inducible long noncoding RNA, LncZFHX2, facilitates DNA repair to mediate osteoarthritis pathology.

Redox Biol. 2023-10

[4]
Targeting transcription factors for therapeutic benefit in rheumatoid arthritis.

Front Immunol. 2023

[5]
In vitro study to identify ligand-independent function of estrogen receptor-α in suppressing DNA damage-induced chondrocyte senescence.

FASEB J. 2023-2

[6]
Sirt6 attenuates chondrocyte senescence and osteoarthritis progression.

Nat Commun. 2022-12-10

[7]
Comet assay for quantification of the increased DNA damage burden in primary human chondrocytes with aging and osteoarthritis.

Aging Cell. 2022-9

[8]
Cellular senescence and senolytics: the path to the clinic.

Nat Med. 2022-8

[9]
Novel role of estrogen receptor-α on regulating chondrocyte phenotype and response to mechanical loading.

Osteoarthritis Cartilage. 2022-2

[10]
The central role of DNA damage in the ageing process.

Nature. 2021-4

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