Fatahi Zahra, Fatahi Mohammad, Haghparast Abbas
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, School of Medicine, Tehran, Iran.
School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran 1439957131 Iran.
EXCLI J. 2024 Jan 3;23:1-17. doi: 10.17179/excli2023-6442. eCollection 2024.
Previous studies have established that the amygdala specifically the basolateral amygdala (BLA), has a fundamental role in decision-making. The present study aimed to investigate functional and neural synchronization between the BLA and anterior cingulate cortex (ACC) while making effort-choice decisions regarding pre-morphine dependence and morphine dependence times. A T-maze decision-making task with a differential outlay (great vs. small effort) and benefit (great vs. small reward) was done, and local field potentials from the BLA and ACC were assessed simultaneously. Results illustrated that in pre-morphine dependence time, when the animals made great reward/great effort decisions, there was a neural synchronization between both regions in beta and gamma frequency bands; and also, in delta, theta, beta, and gamma frequencies while expending effort and climbing the barrier. However, in morphine-dependent rats, during low reward/low effort choice and also during expending low effort, there was just a weak neural coherence in gamma frequency. Besides, there was neural synchronization in theta, beta, and gamma frequencies during reaching great reward in pre-morphine dependence time. Nevertheless, during reaching low reward in morphine dependence time, there was a weaker coherence in beta and gamma compared to pre-morphine dependence. These findings showed that functional and neural coherence between the BLA and ACC has a fundamental role in making the effort-based decision and expending effort. Preference for low reward/low effort, and decrease in expending effort in morphine-dependent rats is partly associated with the changes in the neural coherence between the BLA and ACC.
先前的研究已经证实,杏仁核,特别是基底外侧杏仁核(BLA),在决策过程中起着至关重要的作用。本研究旨在探究在做出关于吗啡依赖前期和吗啡依赖期的努力选择决策时,BLA与前扣带回皮质(ACC)之间的功能和神经同步性。进行了一项具有不同支出(大努力与小努力)和收益(大奖励与小奖励)的T迷宫决策任务,并同时评估了BLA和ACC的局部场电位。结果表明,在吗啡依赖前期,当动物做出大奖励/大努力决策时,两个区域在β和γ频段存在神经同步;并且,在消耗努力并攀爬障碍时,在δ、θ、β和γ频率上也存在神经同步。然而,在吗啡依赖的大鼠中,在低奖励/低努力选择期间以及消耗低努力时,仅在γ频率上存在微弱的神经相干性。此外,在吗啡依赖前期获得大奖励时,θ、β和γ频率上存在神经同步。然而,在吗啡依赖期获得低奖励时,与吗啡依赖前期相比,β和γ频段的相干性较弱。这些发现表明,BLA和ACC之间的功能和神经相干性在基于努力的决策和消耗努力方面起着至关重要的作用。吗啡依赖大鼠对低奖励/低努力的偏好以及努力消耗的减少部分与BLA和ACC之间神经相干性的变化有关。