免疫状态对鸡源病毒可移植性肝癌的影响。
Influence of immune status on virus-derived transplantable hepatoma in chickens.
作者信息
Földes I
出版信息
J Toxicol Environ Health. 1979 Mar-May;5(2-3):517-28. doi: 10.1080/15287397909529763.
The transplantable MC-29 virus-derived hepatoma is a suitable model for studying the influence of immune status on virus-derived hepatomas in chickens. It was found that both humoral and cellular immunologic reactions have a role in the pathogenesis of virus-derived hepatomas and that virus-derived hepatomas can be influenced by nonspecific immunostimulation. The lymphoid system was profoundly altered in hepatoma-bearing chickens; this cannot be neglected when studying correlations between immune reactions and carcinogenesis. Profound changes were also observed in protein synthesis and the steroid receptor system of hepatoma-bearing chickens compared to healthy birds; this also complicates the understanding of the role of immune mechanisms in carcinogenesis.
可移植的MC - 29病毒衍生的肝癌是研究免疫状态对鸡病毒衍生肝癌影响的合适模型。研究发现，体液免疫和细胞免疫反应在病毒衍生肝癌的发病机制中均起作用，且病毒衍生肝癌可受非特异性免疫刺激的影响。荷瘤鸡的淋巴系统发生了深刻变化；在研究免疫反应与致癌作用之间的相关性时，这一点不容忽视。与健康鸡相比，荷瘤鸡的蛋白质合成和类固醇受体系统也观察到了深刻变化；这也使得理解免疫机制在致癌作用中的作用变得复杂。
Zotero 插件