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Clopidogrel for Proteinuria Reduction in Focal Segmental Glomerulosclerosis: Phase 2 Trial Design.

作者信息

Daniel-Fischer Lisa, Antlanger Marlies, Cejka Daniel, Eller Kathrin, Gauckler Philipp, Odler Balazs, Rudnicki Michael, Säemann Marcus D, Schmidt Alice, Sunder-Plassmann Gere, Wiesholzer Martin, Windpessl Martin, Zitt Emanuel, Koenig Franz, Greenbaum Larry A, Kronbichler Andreas, Aufricht Christoph

机构信息

Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.

Department of Internal Medicine 2, Faculty of Medicine, Kepler University Hospital, Johannes Kepler University, Linz, Austria.

出版信息

Kidney Int Rep. 2023 Nov 3;9(2):478-481. doi: 10.1016/j.ekir.2023.10.027. eCollection 2024 Feb.

Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd88/10850994/e2d10003ff1e/gr1.jpg

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Computational drug repositioning of clopidogrel as a novel therapeutic option for focal segmental glomerulosclerosis.
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P2Y12 inhibitor clopidogrel inhibits renal fibrosis by blocking macrophage-to-myofibroblast transition.
Mol Ther. 2022 Sep 7;30(9):3017-3033. doi: 10.1016/j.ymthe.2022.06.019. Epub 2022 Jul 5.
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Interventions for focal segmental glomerulosclerosis in adults.
Cochrane Database Syst Rev. 2022 Feb 28;2(2):CD003233. doi: 10.1002/14651858.CD003233.pub3.
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Antiplatelet agents for chronic kidney disease.
Cochrane Database Syst Rev. 2022 Feb 28;2(2):CD008834. doi: 10.1002/14651858.CD008834.pub4.
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Informing single-arm clinical trials with external controls.
Nat Rev Drug Discov. 2020 Dec;19(12):821-822. doi: 10.1038/d41573-020-00146-5.
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DUET: A Phase 2 Study Evaluating the Efficacy and Safety of Sparsentan in Patients with FSGS.
J Am Soc Nephrol. 2018 Nov;29(11):2745-2754. doi: 10.1681/ASN.2018010091.
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"Threshold-crossing": A Useful Way to Establish the Counterfactual in Clinical Trials?
Clin Pharmacol Ther. 2016 Dec;100(6):699-712. doi: 10.1002/cpt.515. Epub 2016 Oct 19.

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