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远程监测对肾脏病学——腹膜透析标准化结局的影响

Impact of Remote Monitoring on Standardized Outcomes in Nephrology-Peritoneal Dialysis.

作者信息

Centellas-Pérez Francisco Javier, Ortega-Cerrato Agustín, Vera Manel, Devesa-Buch Ramón Jesús, Muñoz-de-Bustillo Eduardo, Prats Mercedes, Alonso-Valente Rafael, Morais José Pedro, Cara-Espada Paula Jaro, Yuste-Lozano Claudia, Montomoli Marco, González-Rico Miguel, Díez-Ojea Beatriz, Barbosa Francesc, Iriarte Miren, Flores Carmen, Quirós-Ganga Pedro Luís, Espinel Laura, Paraíso Vicente, Peña-Ortega María, Manzano Diana, Cancho Bárbara, Pérez-Martínez Juan

机构信息

Albacete General University Hospital, Albacete, Spain.

Hospital Clinic, Barcelona, Spain.

出版信息

Kidney Int Rep. 2023 Nov 5;9(2):266-276. doi: 10.1016/j.ekir.2023.10.034. eCollection 2024 Feb.

Abstract

INTRODUCTION

This study aimed to evaluate the association between the use of remote patient monitoring (RPM) in patients on automated peritoneal dialysis (APD) and the Standardized Outcomes in Nephrology in peritoneal dialysis (SONG-PD) clinical outcomes.

METHODS

A prospective and multicenter cohort study was conducted on patients with advanced chronic kidney disease on APD, recruited at 16 Spanish Hospitals, between June 1 and December 31, 2021. Patients were divided into 2 cohorts, namely patients on APD with RPM (APD-RPM) and patients on APD without RPM. The primary endpoints were the standardized outcomes of the SONG-PD clinical outcomes: PD-associated infection, cardiovascular disease (CVD), mortality rate, technique survival, and life participation (assessed as health-related quality of life [QoL]). Propensity score matching (PSM) was used to evaluate the association of RPM exposure with the clinical outcomes.

RESULTS

A total of 232 patients were included, 176 (75.9%) in the APD-RPM group and 56 (24.1%) in the APD-without-RPM group. The mean patient follow-up time was significantly longer in the APD-RPM group than in the APD-without-RPM group (10.4 ± 2.8 vs. 9.4 ± 3.1 months, respectively;  = 0.02). In the overall study sample, the APD-RPM group was associated with a lower mortality rate (hazard ratio [HR]: 0.08; 95% confidence interval [CI]: 0.01 to 0.69;  = 0.020) and greater technique survival rate (HR: 0.25; 95% CI: 0.11 to 0.59;  = 0.001). After PSM, APD-RPM continued to be associated with better technique survival (HR: 0.23; 95% CI: 0.06 to 0.83;  = 0.024).

CONCLUSION

The use of RPM programs in patients on APD was associated with better survival of the technique and lower mortality rates. However, after PSM, only technique survival was significant.

摘要

引言

本研究旨在评估自动腹膜透析(APD)患者使用远程患者监测(RPM)与腹膜透析肾脏病标准化结局(SONG-PD)临床结局之间的关联。

方法

对2021年6月1日至12月31日期间在16家西班牙医院招募的晚期慢性肾脏病APD患者进行了一项前瞻性多中心队列研究。患者分为2组,即接受RPM的APD患者(APD-RPM)和未接受RPM的APD患者。主要终点是SONG-PD临床结局的标准化结局:腹膜透析相关感染、心血管疾病(CVD)、死亡率、技术生存率和生活参与度(以健康相关生活质量[QoL]评估)。倾向评分匹配(PSM)用于评估RPM暴露与临床结局的关联。

结果

共纳入232例患者,APD-RPM组176例(75.9%),未接受RPM的APD组56例(24.1%)。APD-RPM组患者的平均随访时间显著长于未接受RPM的APD组(分别为10.4±2.8个月和9.4±3.1个月;P = 0.02)。在整个研究样本中,APD-RPM组的死亡率较低(风险比[HR]:0.08;95%置信区间[CI]:0.01至0.69;P = 0.020),技术生存率较高(HR:0.25;95%CI:0.11至0.59;P = 0.001)。PSM后,APD-RPM仍与更好的技术生存率相关(HR:0.23;95%CI:0.06至0.83;P = 0.024)。

结论

APD患者使用RPM程序与更好的技术生存率和更低的死亡率相关。然而,PSM后,只有技术生存率具有显著性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8665/10850997/b9e372247102/ga1.jpg

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