Ghosh Tapas, Bhadra Kakali
Department of Zoology, University of Kalyani, Kalyani, India.
J Biomol Struct Dyn. 2024 Feb 12:1-18. doi: 10.1080/07391102.2024.2314254.
Human serum albumin (HSA) is one of the main protein components of the circulatory system. It's well characterized physiological role is to carry numerous ligands to their target site. Overall pharmacokinetic profile of a drug is deliberately influenced by its affinity towards plasma proteins, especially with albumins. Alkaloids as small molecules are natural nitrogenous organic compounds that have significant medicinal properties that bind to HSA. There are three sites ., I, II and III, on HSA molecule where the drug/small molecule binds based on their molecular size, structure and hydrophobicity. The major driving forces for the interaction of alkaloids-HSA are non-covalent interactions. Drug-HSA interaction is an admired area of research since it has been lately employed for both therapeutic and investigative reasons and is one of the main elements determining the pharmacokinetic and pharmacodynamic profiles of the therapeutic molecules. Displacement and drug-drug interactions, clinical alteration of drug-albumin affinity in diseases affecting the therapeutic role of the drugs, use of HSA nanoparticles for the delivery of drug in cancer are the major significant issues that have been discussed in this review. This article provides an overview of the multifunctional properties of HSA as a drug carrier, as well as how knowledge of these properties is currently being used to improve the bioavailability of drugs with the ability to bind to albumin for future pharmaceutical, clinical, and commercial applications of the albumin protein.Communicated by Ramaswamy H. Sarma.
人血清白蛋白（HSA）是循环系统的主要蛋白质成分之一。其具有明确特征的生理作用是将众多配体运送至靶位点。药物的整体药代动力学特征会受到其与血浆蛋白，尤其是与白蛋白亲和力的有意影响。生物碱作为小分子，是具有重要药用特性且能与HSA结合的天然含氮有机化合物。在HSA分子上有三个位点，即位点I、II和III，药物/小分子会根据其分子大小、结构和疏水性与之结合。生物碱与HSA相互作用的主要驱动力是非共价相互作用。药物与HSA的相互作用是一个备受关注的研究领域，因为它近来已被用于治疗和研究目的，并且是决定治疗分子药代动力学和药效学特征的主要因素之一。置换和药物-药物相互作用、影响药物治疗作用的疾病中药物与白蛋白亲和力的临床改变、使用HSA纳米颗粒在癌症中递送药物，是本综述中讨论的主要重要问题。本文概述了HSA作为药物载体的多功能特性，以及目前如何利用这些特性的知识来提高能够与白蛋白结合的药物的生物利用度，以用于白蛋白蛋白未来的制药、临床和商业应用。由拉马斯瓦米·H·萨尔马传达。
