RNA m6A 修饰在非酒精性脂肪性肝病中的作用。
Roles of RNA m6A modification in nonalcoholic fatty liver disease.
机构信息
The Department of Medical Genetics, Naval Medical University, Shanghai, China.
The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital Affiliated to Naval Medical University, Shanghai, China.
出版信息
Hepatol Commun. 2023 Jan 27;7(2):e0046. doi: 10.1097/HC9.0000000000000046. eCollection 2023 Feb 1.
NAFLD is a series of liver disorders, and it has become the most prevalent hepatic disease to date. However, there are no approved and effective pharmaceuticals for NAFLD owing to a poor understanding of its pathological mechanisms. While emerging studies have demonstrated that m6A modification is highly associated with NAFLD. In this review, we summarize the general profile of NAFLD and m6A modification, and the role of m6A regulators including erasers, writers, and readers in NAFLD. Finally, we also highlight the clinical significance of m6A in NAFLD.
非酒精性脂肪性肝病 (NAFLD) 是一系列肝脏疾病，它已成为迄今为止最普遍的肝脏疾病。然而，由于对其病理机制缺乏了解，目前还没有批准和有效的药物可用于治疗非酒精性脂肪性肝病。虽然新兴的研究表明 m6A 修饰与 NAFLD 高度相关。在这篇综述中，我们总结了 NAFLD 和 m6A 修饰的一般概况，以及 m6A 调节剂（包括擦除剂、书写器和阅读器）在 NAFLD 中的作用。最后，我们还强调了 m6A 在 NAFLD 中的临床意义。
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