Department of Dermatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Pediatr Dermatol. 2024 May-Jun;41(3):551-553. doi: 10.1111/pde.15546. Epub 2024 Feb 12.
Anaplastic lymphoma kinase (ALK)-positive histiocytosis is a rare disease that usually occurs in infants and young children and is characterized by ALK-positive histiocytes infiltrating organs. We present a case of multisystem involvement of ALK-positive histiocytosis in a female infant with skin nodules as the initial presentation. Despite multiorgan involvement, most tumors had spontaneously regressed, and all bones were partially healed after 40 months of regular follow-up without treatment. However, gait abnormalities persisted, indicating that early treatment may have greater impact in maintaining a child's quality of life when the disease involves the brain or the critical period of bone development.
间变性淋巴瘤激酶（ALK）阳性组织细胞增生症是一种罕见疾病，通常发生于婴儿和幼儿，其特征是 ALK 阳性组织细胞浸润各器官。我们报告了一例女性婴儿以皮肤结节为首发表现的 ALK 阳性组织细胞增生症多系统受累病例。尽管存在多器官受累，但大多数肿瘤自发消退，所有骨骼在未经治疗的情况下经过 40 个月的定期随访后部分愈合。然而，步态异常仍存在，这表明当疾病累及大脑或骨骼发育关键期时，早期治疗可能对维持儿童的生活质量有更大影响。
