Garte Seymour
Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, 160 Frelinghuysen Road, Piscataway, NJ, 08854-8020, USA.
Biosystems. 2024 Mar;237:105154. doi: 10.1016/j.biosystems.2024.105154. Epub 2024 Feb 10.
Since the Origin of Species, it has been known that evolution depends on what Darwin called the "strong principle of inheritance." Highly accurate replication of cellular phenotype is a universal phenomenon in all of life since LUCA and is often taken for granted as a constant in evolutionary theory. It is not known how self-replication arose during the origin of life. In this report I use the simple mathematics of evolutionary theory to investigate the dynamics of self-replication accuracy and allelic selection. Results indicate that the degree of self-replication accuracy must be greater than a threshold related to the selection coefficients of the alleles in a population in order for evolution to occur. Accurate replication of cellular phenotype and of the molecules involved in genotype/phenotype linkage is necessary for the origin of evolution and may be considered the fundamental principle of life.
自《物种起源》问世以来，人们就知道进化依赖于达尔文所说的“强大的遗传原则”。自“最后的共同祖先”（LUCA）以来，细胞表型的高度精确复制是所有生命中的普遍现象，并且在进化理论中常常被视为一种常量而被视作理所当然。目前尚不清楚自我复制在生命起源过程中是如何出现的。在本报告中，我运用进化理论的简单数学方法来研究自我复制准确性和等位基因选择的动态变化。结果表明，为了使进化发生，自我复制准确性的程度必须大于与种群中等位基因选择系数相关的一个阈值。细胞表型以及参与基因型/表型联系的分子的精确复制是进化起源所必需的，并且可以被视为生命的基本原理。
