癌症中的真菌
Fungi in cancer.
作者信息
Galloway-Peña Jessica, Iliev Iliyan D, McAllister Florencia
机构信息
Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.
出版信息
Nat Rev Cancer. 2024 May;24(5):295-298. doi: 10.1038/s41568-024-00665-y. Epub 2024 Feb 12.
Abstract
Both the gut and the tumour microbiome are now established as crucial regulators of cancer phenotypes and have been implicated in cancer initiation, progression and therapy response. Although the role of bacteria in these processes is beginning to be unravelled, the relevance of fungi is only just emerging. In this Viewpoint, we asked experts to discuss the current knowledge on the mycobiome–cancer connection and share their opinion on how to best solve open questions.
摘要
肠道微生物群和肿瘤微生物群现已被确认为癌症表型的关键调节因子，并与癌症的发生、发展及治疗反应有关。虽然细菌在这些过程中的作用正逐渐被揭示，但真菌的相关性才刚刚显现。在本观点文章中，我们邀请专家讨论目前关于真菌微生物群与癌症关联的知识，并就如何最好地解决悬而未决的问题分享他们的看法。
相似文献
1
Fungi in cancer.癌症中的真菌
Nat Rev Cancer. 2024 May;24(5):295-298. doi: 10.1038/s41568-024-00665-y. Epub 2024 Feb 12.
2
Role of Fungi in Tumorigenesis: Promises and Challenges.真菌在肿瘤发生中的作用：前景与挑战。
Annu Rev Pathol. 2025 Jan;20(1):459-482. doi: 10.1146/annurev-pathmechdis-111523-023524.
3
Host-microbe interactions: fungi.宿主-微生物相互作用：真菌
Curr Opin Microbiol. 2008 Aug;11(4):303-4. doi: 10.1016/j.mib.2008.07.001. Epub 2008 Jul 24.
4
Catch the wave: Metabolomic analyses in human pathogenic fungi.紧跟潮流：人类致病真菌的代谢组学分析
PLoS Pathog. 2020 Aug 20;16(8):e1008757. doi: 10.1371/journal.ppat.1008757. eCollection 2020 Aug.
5
Cell surface hydrophobicity and medically important fungi.细胞表面疏水性与医学重要真菌
Curr Top Med Mycol. 1995;6:1-31.
6
Recent progress in understanding host-fungal interactions.宿主-真菌相互作用研究的最新进展。
Curr Opin Microbiol. 2000 Aug;3(4):337-8. doi: 10.1016/s1369-5274(00)00099-0.
7
The emergence of fungi as major hospital pathogens.真菌作为主要医院病原体的出现。
J Hosp Infect. 1988 Feb;11 Suppl A:411-26. doi: 10.1016/0195-6701(88)90220-4.
8
Pathocycles.致病周期
Fungal Genet Biol. 2008 Jan;45(1):1-5. doi: 10.1016/j.fgb.2007.02.009. Epub 2007 Feb 28.
9
Melanins and their importance in pathogenic fungi.黑色素及其在致病真菌中的重要性。
Curr Top Med Mycol. 1988;2:338-87. doi: 10.1007/978-1-4612-3730-3_10.
10
Fungal infections in cancer patients.癌症患者的真菌感染
Cancer Treat Res. 2014;161:129-55. doi: 10.1007/978-3-319-04220-6_4.
引用本文的文献
1
The multi-kingdom cancer microbiome.多界癌症微生物组
Nat Microbiol. 2025 Sep 9. doi: 10.1038/s41564-025-02103-7.
2
Fungi and cancer: unveiling the complex role of fungal infections in tumor biology and therapeutic resistance.真菌与癌症：揭示真菌感染在肿瘤生物学和治疗耐药性中的复杂作用
Front Cell Infect Microbiol. 2025 Jun 10;15:1596688. doi: 10.3389/fcimb.2025.1596688. eCollection 2025.
3
The gastrointestinal mycobiome in inflammation and cancer: unraveling fungal dysbiosis, pathogenesis, and therapeutic potential.炎症与癌症中的胃肠道真菌群落：揭示真菌生态失调、发病机制及治疗潜力
Med Oncol. 2025 May 5;42(6):195. doi: 10.1007/s12032-025-02761-x.
4
Unveiling the fungal frontier: mycological insights into inflammatory bowel disease.揭开真菌领域的面纱：对炎症性肠病的真菌学见解。
Front Immunol. 2025 Mar 26;16:1551289. doi: 10.3389/fimmu.2025.1551289. eCollection 2025.
5
Mycobiome: an underexplored kingdom in cancer.真菌微生物组：癌症中一个未被充分探索的领域。
Microbiol Mol Biol Rev. 2025 Jun 25;89(2):e0026124. doi: 10.1128/mmbr.00261-24. Epub 2025 Mar 14.
6
Microbes, macrophages, and melanin: a unifying theory of disease as exemplified by cancer.微生物、巨噬细胞与黑色素：以癌症为例的疾病统一理论
Front Immunol. 2025 Feb 6;15:1493978. doi: 10.3389/fimmu.2024.1493978. eCollection 2024.
7
Role of Fungi in Tumorigenesis: Promises and Challenges.真菌在肿瘤发生中的作用：前景与挑战。
Annu Rev Pathol. 2025 Jan;20(1):459-482. doi: 10.1146/annurev-pathmechdis-111523-023524.
8
The mycobiome in human cancer: analytical challenges, molecular mechanisms, and therapeutic implications.人类癌症中的真菌群落：分析挑战、分子机制及治疗意义。
Mol Cancer. 2025 Jan 15;24(1):18. doi: 10.1186/s12943-025-02227-8.
9
Inflammation and Immunity in Liver Neoplasms: Implications for Future Therapeutic Strategies.肝脏肿瘤中的炎症与免疫：对未来治疗策略的启示
Mol Cancer Ther. 2025 Feb 4;24(2):188-199. doi: 10.1158/1535-7163.MCT-23-0726.
本文引用的文献
1
Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19.真菌微生物群在严重 COVID-19 中维持中性粒细胞及其前体细胞的持久免疫激活。
Nat Immunol. 2023 Nov;24(11):1879-1889. doi: 10.1038/s41590-023-01637-4. Epub 2023 Oct 23.
2
Major data analysis errors invalidate cancer microbiome findings.主要数据分析错误使癌症微生物组研究结果无效。
mBio. 2023 Oct 31;14(5):e0160723. doi: 10.1128/mbio.01607-23. Epub 2023 Oct 9.
3
Caution regarding the specificities of pan-cancer microbial structure.警惕泛癌微生物结构的特异性。
Microb Genom. 2023 Aug;9(8). doi: 10.1099/mgen.0.001088.
4
Revisiting the intrinsic mycobiome in pancreatic cancer.重新审视胰腺癌中的固有真菌组。
Nature. 2023 Aug;620(7972):E1-E6. doi: 10.1038/s41586-023-06292-1. Epub 2023 Aug 2.
5
Characterization of the intestinal fungal microbiome in patients with hepatocellular carcinoma.肝细胞癌患者肠道真菌微生物组的特征。
J Transl Med. 2023 Feb 15;21(1):126. doi: 10.1186/s12967-023-03940-y.
6
A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors.一项泛癌真菌微生物组分析揭示了真菌与胃肠道和肺部肿瘤的关联。
Cell. 2022 Sep 29;185(20):3807-3822.e12. doi: 10.1016/j.cell.2022.09.015.
7
Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions.泛癌分析揭示了癌症类型特异性真菌生态和细菌群落相互作用。
Cell. 2022 Sep 29;185(20):3789-3806.e17. doi: 10.1016/j.cell.2022.09.005.
8
Bacterial-fungal metabolic interactions within the microbiota and their potential relevance in human health and disease: a short review.微生物群内细菌-真菌代谢相互作用及其与人类健康和疾病的潜在相关性：简短综述。
Gut Microbes. 2022 Jan-Dec;14(1):2105610. doi: 10.1080/19490976.2022.2105610.
9
Immune regulation by fungal strain diversity in inflammatory bowel disease.真菌菌株多样性对炎症性肠病的免疫调节。
Nature. 2022 Mar;603(7902):672-678. doi: 10.1038/s41586-022-04502-w. Epub 2022 Mar 16.
10
Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer.真菌微生物组驱动胰腺癌中的 IL-33 分泌和 2 型免疫。
Cancer Cell. 2022 Feb 14;40(2):153-167.e11. doi: 10.1016/j.ccell.2022.01.003. Epub 2022 Feb 3.
Zotero 插件