Spormann H, Willgeroth C, Tautenhahn P
Zentralbl Allg Pathol. 1985;130(6):545-50.
The case of a 50-year-old woman with a ruptured liver caused by peliosis hepatis is presented. Death occurred three days after laparotomy for an acute abdomen with a clinical diagnosis of intra-abdominal hemorrhage. Autopsy findings including histology are presented and the possible pathogenetic mechanisms are discussed. There was neither evidence of a tumor nor of drug or toxin exposure. Known etiologic factors for this disorder are discussed on the basis of the medical literature. These include consumptive primary disorders, anabolic agents and oral contraceptives. The pathogenetic sequence involves damage to the endothelial cells of the hepatic sinuses and to the reticular fiber network. This case should make physicians aware of this infrequent iatrogenic disorder which is apparently increasing in its occurrence.
本文报告了一例因肝紫癜导致肝脏破裂的50岁女性病例。患者因临床诊断为腹腔内出血的急腹症接受剖腹手术后三天死亡。文中呈现了尸检结果，包括组织学检查结果，并讨论了可能的发病机制。既没有肿瘤证据，也没有药物或毒素暴露的证据。根据医学文献，讨论了该疾病已知的病因。这些病因包括消耗性原发性疾病、合成代谢药物和口服避孕药。发病机制包括肝窦内皮细胞和网状纤维网络受损。该病例应使医生认识到这种罕见的医源性疾病，其发病率显然正在上升。
