Jiang Jianbo, Sun Lili, Huang Meixia
Pediatric Department, Hangzhou Fuyang Women and Children Hospital, Zhejiang Province, 311400, China.
Obstetric Department, Hangzhou Fuyang Women and Children Hospital, Zhejiang Province, 311400, China.
Iran J Immunol. 2024 Mar 12;21(1):81-88. doi: 10.22034/iji.2024.99509.2648.
Human adenovirus (HAdV) is an enveloped icosahedral DNA virus. HAdV infection can lead to immune system damage, resulting in decreased numbers and compromised function of T cells and B cells. It can also cause an imbalanced Th1/Th2 ratio and dysregulation of pro-inflammatory and anti-inflammatory cytokines.
To investigate the serum levels of interleukin (IL)-13 and IL-17A in children with HAdV pneumonia.
Pediatric patients diagnosed with HAdV pneumonia were divided into a non-severe group or a severe group based on the severity of their condition. Patients in the severe group were further classified into good and poor prognosis subgroups. We collected 2-2.5 mL of venous blood from each patient, which was then centrifuged. Using an ELISA detection kit, we determined the concentrations of IL-13 and IL-17A.
Patients with a severe condition exhibited significantly higher serum concentrations of IL-13 and IL-17A than the non-severe cases. Out of 50 severe cases, 32 had good prognoses, while 18 cases showed poor prognoses. Patients with poor prognoses showed significantly higher serum concentrations of IL-13 compared to those with good prognoses.
Serum concentrations of IL-13 and IL-17A are potential diagnostic markers for pediatric patients with severe HAdV pneumonia. Additionally, they demonstrate good predictive value for a poor prognosis in severe pneumonia cases.
人腺病毒（HAdV）是一种有包膜的二十面体DNA病毒。HAdV感染可导致免疫系统损伤，致使T细胞和B细胞数量减少及功能受损。它还可引起Th1/Th2比例失衡以及促炎和抗炎细胞因子的失调。
探讨HAdV肺炎患儿血清白细胞介素（IL）-13和IL-17A水平。
将诊断为HAdV肺炎的儿科患者根据病情严重程度分为非重症组或重症组。重症组患者进一步分为预后良好和预后不良亚组。我们从每位患者采集2 - 2.5 mL静脉血，然后进行离心。使用ELISA检测试剂盒测定IL-13和IL-17A的浓度。
重症患者血清中IL-13和IL-17A的浓度显著高于非重症患者。50例重症患者中，32例预后良好，18例预后不良。预后不良患者血清中IL-13的浓度显著高于预后良好的患者。
IL-13和IL-17A的血清浓度是重症HAdV肺炎儿科患者的潜在诊断标志物。此外，它们对重症肺炎病例的不良预后具有良好的预测价值。
