Zhao Runsheng, Fan Rui, Wan Weiqing
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, P.R. China.
China National Clinical Research Center for Neurological Diseases, Beijing 100050, P.R. China.
Oncol Lett. 2024 Jan 25;27(3):121. doi: 10.3892/ol.2024.14256. eCollection 2024 Mar.
Multiple primary intracranial tumors, or the presence of two or more primary intracranial tumors, are a rare clinical occurrence. The current study presents the case of a 28-year-old patient with concurrent left vestibular schwannoma, left cerebellar hemisphere dermoid cyst and craniovertebral junction malformation, specifically basilar invagination and Klippel-Feil syndrome. The patient exhibited symptoms of torticollis and recurrent headaches, with no apparent hearing loss. A far lateral approach was selected for surgical resection to address these complex conditions and achieve gross total resection in a single-stage surgery while preserving both facial and auditory nerve function. Successful gross total resection was achieved and the function of both nerves was effectively preserved. Of note, the coexistence of vestibular schwannoma and dermoid cyst in the same patient has not been documented in the existing literature. The present study provided a comprehensive account of the presentation and progression of this uncommon medical scenario. Furthermore, a surgical principle for the management of multiple primary intracranial tumors was proposed.
多发性原发性颅内肿瘤，即存在两个或更多原发性颅内肿瘤，是一种罕见的临床情况。本研究报告了一例28岁患者，同时患有左侧前庭神经鞘瘤、左侧小脑半球皮样囊肿和颅颈交界畸形，具体为基底凹陷和Klippel-Feil综合征。患者表现为斜颈和反复头痛，无明显听力损失。选择远外侧入路进行手术切除，以处理这些复杂情况，并在一期手术中实现肿瘤全切，同时保留面神经和听神经功能。手术成功实现了肿瘤全切，且有效保留了两条神经的功能。值得注意的是，现有文献中尚未记载同一患者同时存在前庭神经鞘瘤和皮样囊肿的情况。本研究全面阐述了这一罕见医学情况的表现和进展。此外，还提出了处理多发性原发性颅内肿瘤的手术原则。
