Shirai Y, Sunakawa K, Ichihashi Y, Yamaguchi H
Exp Pathol (Jena). 1979;17(3):158-66. doi: 10.1016/s0014-4908(79)80023-x.
The morphological manifestation of the intestinal infections of Salmonella typhimurium by the intestine rolled method in both conventional DKI and germfree mice have been investigated in our laboratory. In the conventional mice, the morphological manifestation of intestinal infection shows no difference from the general features of infection, while in the germfree mice, the manifestation is characterized by the so-called non-reactive necrotizing enteritis without cellular reaction. When infection in the germfree mice occurs, some state of immunological insufficiency should be taken into consideration. In infections of germfree mice it is difficult to consider the immunological or the allergic reaction which is expected in the conventional mice. In addition, the direct influences of bacteria such as endotoxin must be taken into consideration as another possibility, but the very limited localized lesions, as seen in this experiment cannot always be suggested to be due to the direct influence of bacteria or intoxication. Though there are many problems to be solved in the future, we are now able to state a kind of mechanism similar to that of Shwartzman's phenomenon cannot be ignored in the infection in newborns or in immunologically immature animals.
我们实验室采用肠卷法对常规DKI小鼠和无菌小鼠感染鼠伤寒沙门氏菌后的肠道感染形态学表现进行了研究。在常规小鼠中，肠道感染的形态学表现与一般感染特征无差异，而在无菌小鼠中，其表现特征为所谓的无细胞反应的非反应性坏死性肠炎。当无菌小鼠发生感染时，应考虑某种免疫功能不全的状态。在无菌小鼠感染中，很难考虑常规小鼠中预期的免疫或过敏反应。此外，必须考虑细菌如内毒素的直接影响作为另一种可能性，但如本实验所见的非常有限的局部病变并不总是能表明是由于细菌的直接影响或中毒所致。尽管未来有许多问题有待解决，但我们现在能够指出，在新生儿或免疫未成熟动物的感染中，一种类似于施瓦茨曼现象的机制不可忽视。
