Chao Di, Liu Tong-Xin, Zhang Pengling, Xia Shilu, Yang Panting, Huang Mengjiao, Liu Qingfeng, Zhang Guisheng
Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China.
Org Lett. 2024 Feb 23;26(7):1432-1436. doi: 10.1021/acs.orglett.4c00043. Epub 2024 Feb 13.
An interrupted N-heterocyclic carbene-catalyzed radical coupling strategy is disclosed for efficient alkylation and arylation of [60]fullerene. This novel and general strategy bridges the gap between organocatalytic radical cross-coupling and functionalization of fullerenes. Readily available feedstocks, remarkably broad substrate scope and functional group compatibility, and convenient late-stage nanomodification of complex molecules make this strategy with incomparable diversity and practicality in the synthesis of monoalkylated and -arylated fullerenes.
公开了一种用于[60]富勒烯高效烷基化和芳基化的间断N-杂环卡宾催化自由基偶联策略。这种新颖且通用的策略弥合了有机催化自由基交叉偶联与富勒烯功能化之间的差距。易于获得的原料、显著广泛的底物范围和官能团兼容性，以及复杂分子便捷的后期纳米修饰，使得该策略在单烷基化和单芳基化富勒烯的合成中具有无与伦比的多样性和实用性。
