From the Department of Ophthalmology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan (Komatsu, Masuda, Iida, Ichihara, Nakano); Department of Pathology, TheJikei University School of Medicine, Minato-ku, Tokyo, Japan (Iwauchi, Kubota, Iwamoto, Shimoda); Department of Ophthalmology, Tokai University School of Medicine, Isehara, Kanagawa, Japan (Kawai); Support Office for Bioresource Research, Center for Translational Research, Translational Research Headquarters, Fujita Health University, Toyoake, Aichi, Japan (Yamamoto).
J Cataract Refract Surg. 2024 Jun 1;50(6):611-617. doi: 10.1097/j.jcrs.0000000000001413.
To explore lens capsule pathological characteristics in intraocular lens (IOL) dislocation after cataract surgery in patients with atopic dermatitis (AD).
University hospital department of ophthalmology.
Case series with clinicopathological correlations.
Lens capsules and surrounding tissues excised during surgery from eyes with AD (AD group) and eyes without AD (non-AD group) with IOL dislocation were histologically evaluated. Hematoxylin and eosin staining was used to assess abnormal changes in lens epithelial cells (LECs). Masson trichrome staining distinguished the fibrous metaplasia around the lens capsule into high-density and low-density fibrosis. Capsular splitting (thinning) was identified in both stained preparations.
The IOL dislocation morphology in the AD group (10 eyes of 10 patients) included 7 cases of capsular bag dislocation (CBD) and 3 cases of dead bag syndrome (DBS), with an average duration to IOL dislocation of 11.5 ± 5.6 years. All patients in the non-AD group (12 eyes of 12 patients) had CBD, averaging 10.2 ± 5.7 years to dislocation. Abnormal LECs, low-density fibrosis, and capsular splitting were observed in 9 (90), 9 (90), and 6 (60) of the patients in the AD group compared with 6 (50), 3 (25), and 2 (18), respectively, in the non-AD group (total n [%]).
Compared with the non-AD group, the AD group exhibited higher frequencies of morphological changes in LECs, low-density fibrosis around the lens capsule, and capsular splitting characteristics of DBS. These results suggest LEC degeneration and increased lens capsule fragility occurred in patients with AD.
探讨特应性皮炎（AD）患者白内障术后人工晶状体（IOL）脱位的晶状体囊病理特征。
大学医院眼科。
临床病理相关性病例系列。
对 AD 组（AD 组）和无 AD 组（非 AD 组）IOL 脱位患者手术切除的晶状体囊及周围组织进行组织学评估。苏木精-伊红染色用于评估晶状体上皮细胞（LEC）的异常变化。Masson 三色染色将晶状体囊周围的纤维化生分为高密度和低密度纤维化。在两种染色制剂中均可识别囊膜分裂（变薄）。
AD 组（10 例 10 眼）的 IOL 脱位形态包括 7 例囊袋脱位（CBD）和 3 例死袋综合征（DBS），IOL 脱位平均时间为 11.5±5.6 年。非 AD 组（12 例 12 眼）所有患者均为 CBD，脱位平均时间为 10.2±5.7 年。AD 组中 9（90）例、9（90）例和 6（60）例患者观察到异常 LEC、低密度纤维化和囊膜分裂，而非 AD 组分别为 6（50）例、3（25）例和 2（18）例（总 n [%]）。
与非 AD 组相比，AD 组 LEC、晶状体囊周围低密度纤维化和 DBS 囊膜分裂的形态变化发生率更高。这些结果表明 AD 患者的 LEC 变性和晶状体囊脆性增加。
