Yao Yexuan, Ma Li, Yu Chengwei, Cheng Ce, Gao Hongxia, Wei Teng, Li Litong, Wang Zhiyue, Liu Wei, Deng Zeyuan, Zou Liqiang, Luo Ting
State Key Laboratory of Food Science and Resources, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, Jiangxi, China.
School of Health, Jiangxi Normal University, Nanchang 330022, China.
Food Chem. 2024 Jul 1;445:138661. doi: 10.1016/j.foodchem.2024.138661. Epub 2024 Feb 4.
To improve the poor water solubility and oral bioavailability of tyrosol, novel tyrosol liposomes (Tyr-LPs) were prepared by pH-driven method. Fourier transform infrared (FTIR) absorption spectra and X-ray diffraction (XRD) analysis indicated that Tyr-LPs were successfully encapsulated and tyrosol was in an amorphous state in liposomes. When tyrosol content in Tyr-LP was 1.33 mg/ml and the Tyr:LP (mass ratio) = 1:2, favorable dispersibility of Tyr-LP was exhibited, with an instability index of 0.049 ± 0.004, PDI of 0.274 ± 0.003, and the EE of 94.8 ± 2.5 %. In vivo pharmacokinetic studies showed that after oral administration of tyrosol or Tyr-LP (Tyr:LP = 1:2), concentration-versus-time curve (AUC) and maximum concentration (C) values of Tyr-LP was respectively 1.5-fold (P < 0.01) and 2.25-fold (P < 0.01) higher than tyrosol, which indicated that the oral bioavailability of tyrosol was effectively improved in Tyr-LPs. Our study thereby provides theoretical support for the application of Tyr-LP for optimal delivery of tryosol.
为改善酪醇的低水溶性和口服生物利用度，采用pH驱动法制备了新型酪醇脂质体（Tyr-LPs）。傅里叶变换红外（FTIR）吸收光谱和X射线衍射（XRD）分析表明，Tyr-LPs被成功包封，且酪醇在脂质体中呈无定形状态。当Tyr-LP中酪醇含量为1.33 mg/ml且酪醇与脂质体的质量比（Tyr:LP）为1:2时，Tyr-LP表现出良好的分散性，不稳定指数为0.049±0.004，多分散指数（PDI）为0.274±0.003，包封率（EE）为94.8±2.5%。体内药代动力学研究表明，口服酪醇或Tyr-LP（Tyr:LP = 1:2）后，Tyr-LP的浓度-时间曲线下面积（AUC）和最大浓度（C）值分别比酪醇高1.5倍（P < 0.01）和2.25倍（P < 0.01），这表明酪醇在Tyr-LPs中的口服生物利用度得到了有效提高。因此，我们的研究为Tyr-LP用于酪醇的最佳递送应用提供了理论支持。
