Di Lorenzo M, Gambelli G C, Boccanelli A
G Ital Cardiol. 1985 Dec;15(12):1200-4.
During Ergonovine-test a patient with Prinzmetal angina presented (in I, aVL, V3-V6) ST downsloping which, after a temporary phase of alternative normalization (AST) beat to beat in V5, progressed to ST upsloping with typical angina. The M-mode echo-study first discovered, before than ecg, septal impairment (hypokinesia which increased to akinesia in the AST phase) and also asynergy of posterior wall of left ventricle. After intravenous nitrate echo-alterations reversed more rapidly than ecg one (transitional phase of ST decrease). The authors relate the AST to temporary alternative pseudonormalization caused by a phase of electrical instability during progressive vasospastic ischemia involving first the endocardial layers and after the epicardium of a single myocardiocoronary district. Probably also other partially opposite ischaemic districts, as suggested from echo data of posterior wall asynergy took a part in these events. This rare ST-alternans type as new pseudonormalization phenomenon and the usefulness of echo-study during ischaemic attacks are stressed.
在麦角新碱试验期间,一名变异型心绞痛患者在I、aVL、V3-V6导联出现ST段下斜型压低,在V5导联逐搏出现短暂的交替性正常化(AST)阶段后,进展为伴有典型心绞痛的ST段上斜型改变。M型超声心动图研究在心电图之前首先发现了室间隔损害(运动减退,在AST阶段发展为运动不能)以及左心室后壁运动不协调。静脉注射硝酸酯后,超声心动图改变比心电图改变逆转更快(ST段下降的过渡阶段)。作者将AST与在进行性血管痉挛性缺血期间由电不稳定阶段引起的暂时性交替性假性正常化相关联,这种缺血首先累及单个心肌冠状动脉区域的心内膜层,随后累及心外膜。根据后壁运动不协调的超声数据提示,可能还有其他部分相反的缺血区域参与了这些事件。强调了这种罕见的ST段交替型作为新的假性正常化现象以及缺血发作期间超声心动图研究的有用性。