Department of Pathology, School of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, 6526, Wolstein Research Building, 2103 Cornell Road, Cleveland, OH, 44106, USA.
The Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
Cell Mol Life Sci. 2024 Feb 14;81(1):89. doi: 10.1007/s00018-023-05108-9.
Sam68 is a ubiquitously expressed KH-domain containing RNA-binding protein highly studied for its involvement in regulating multiple steps of RNA metabolism. Sam68 also contains multiple protein-protein interaction regions such as proline-rich regions, tyrosine phosphorylation sites, and arginine methylation sites, all of which facilitate its participation as an adaptor protein in multiple signaling pathways, likely independent of its RNA-binding role. This review focuses on providing a comprehensive report on the adaptor roles of Sam68 in inflammatory signaling and inflammatory diseases. The insights presented here have the potential to open new avenues in inflammation research and justify targeting Sam68 to control aberrant inflammatory responses.
Sam68 是一种广泛表达的 KH 结构域 RNA 结合蛋白，因其参与调节 RNA 代谢的多个步骤而受到深入研究。Sam68 还包含多个蛋白质-蛋白质相互作用区域，如富含脯氨酸的区域、酪氨酸磷酸化位点和精氨酸甲基化位点，所有这些都有助于其作为多种信号通路中的衔接蛋白参与，可能与其 RNA 结合作用无关。本综述重点介绍 Sam68 在炎症信号和炎症性疾病中的衔接作用，提供全面的报告。这里提出的见解有可能为炎症研究开辟新的途径，并证明靶向 Sam68 以控制异常炎症反应是合理的。
Zotero 插件
