Krishna Sai, Bhaskaran Rajprakash, Kumar Santhosh P, Krishnan Murugesan
Oral and Maxillofacial Surgery, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Cureus. 2024 Jan 14;16(1):e52245. doi: 10.7759/cureus.52245. eCollection 2024 Jan.
Background Though various advancements came into the field of surgery to do the atraumatic procedure, post-operative pain, and swelling are unavoidable complications. Hence, various medicaments are packed in the extracted third molar sockets to prevent these post-operative complications. Aim The study aimed to evaluate the efficacy of oxytetracycline hydrocortisone-soaked gauze in reducing post-operative pain and swelling compared to conventional surgical procedures without any packing in patients undergoing surgical extraction of the impacted mandibular third molars. Materials and methods The study was conducted in the Department of Oral and Maxillofacial Surgery at Saveetha Dental College and Hospitals, Chennai. In this study, 50 patients were randomly included in two groups of 25 participants each. In group A, oxytetracycline hydrocortisone-soaked gauze was placed, and in group B, conventional closure was done without any pack after surgical removal of impacted mandibular third molars. Post-operative pain was assessed on days one, three, and five using a 10-point visual analog scale. Post-operative swelling was assessed on the third and seventh days using a four-point swelling measurement. Data analysis was done using SPSS (IBM Corp. Armonk, NY). A p-value less than 0.05 was considered statistically significant. Independent sample t-test was done to compare the outcomes between the two groups. Results The results demonstrated that group A (Oxytetracycline Hydrocortisone-soaked gauze) showed superior pain reduction compared to group B (conventional closure) at all post-operative intervals (P=0.001). Moreover, group A exhibited reduced swelling, resulting in higher patient satisfaction levels compared to group B on the third post-operative day (P=0.001). Conclusion It can be concluded from the study that there was a significant reduction in post-operative pain and swelling with the use of oxytetracycline hydrocortisone-soaked gauze, as it acts like a local drug delivery system in patients undergoing impacted mandibular third molar surgeries.
尽管外科领域出现了各种进步技术以实现无创伤手术，但术后疼痛和肿胀仍是不可避免的并发症。因此，人们会在拔除的第三磨牙牙槽窝内填充各种药物以预防这些术后并发症。
本研究旨在评估与未进行任何填充的传统手术方法相比，土霉素氢化可的松浸泡纱布在减轻接受下颌阻生第三磨牙拔除手术患者术后疼痛和肿胀方面的疗效。
本研究在钦奈萨维塔牙科学院及医院的口腔颌面外科进行。在本研究中，50名患者被随机分为两组，每组25名参与者。A组放置土霉素氢化可的松浸泡纱布，B组在拔除下颌阻生第三磨牙后进行传统缝合且不进行任何填充。术后第1天、第3天和第5天使用10分视觉模拟量表评估术后疼痛。术后第3天和第7天使用4分肿胀测量法评估术后肿胀。使用SPSS（IBM公司，纽约州阿蒙克）进行数据分析。p值小于0.05被认为具有统计学意义。采用独立样本t检验比较两组结果。
结果表明，在所有术后时间段，A组（土霉素氢化可的松浸泡纱布）的疼痛减轻程度均优于B组（传统缝合）（P = 0.001）。此外，A组肿胀减轻，与B组相比，术后第3天患者满意度更高（P = 0.001）。
从该研究可以得出结论，使用土霉素氢化可的松浸泡纱布可显著减轻术后疼痛和肿胀，因为它在接受下颌阻生第三磨牙手术的患者中起到了局部给药系统的作用。
