Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Front Endocrinol (Lausanne). 2024 Jan 30;14:1290130. doi: 10.3389/fendo.2023.1290130. eCollection 2023.
Bone metabolism is the basis for maintaining the normal physiological state of bone, and imbalance of bone metabolism can lead to a series of metabolic bone diseases. As a member of the IL-6 family, IL-11 acts primarily through the classical signaling pathway IL-11/Receptors, IL-11 (IL-11R)/Glycoprotein 130 (gp130). The regulatory role of IL-11 in bone metabolism has been found earlier, but mainly focuses on the effects on osteogenesis and osteoclasis. In recent years, more studies have focused on IL-11's roles and related mechanisms in different bone metabolism activities. IL-11 regulates osteoblasts, osteoclasts, BM stromal cells, adipose tissue-derived mesenchymal stem cells, and chondrocytes. It's involved in bone homeostasis, including osteogenesis, osteolysis, bone marrow (BM) hematopoiesis, BM adipogenesis, and bone metastasis. This review exams IL-11's role in pathology and bone tissue, the cytokines and pathways that regulate IL-11 expression, and the feedback regulations of these pathways.
骨代谢是维持骨骼正常生理状态的基础，骨代谢失衡可导致一系列代谢性骨病。IL-11 作为 IL-6 家族的一员，主要通过经典信号通路 IL-11/受体、IL-11（IL-11R）/糖蛋白 130（gp130）发挥作用。IL-11 在骨代谢中的调节作用较早被发现，但主要集中在对成骨和破骨的影响上。近年来，更多的研究集中在 IL-11 在不同骨代谢活动中的作用和相关机制上。IL-11 调节成骨细胞、破骨细胞、BM 基质细胞、脂肪组织来源的间充质干细胞和成软骨细胞。它参与骨稳态，包括成骨、骨吸收、骨髓（BM）造血、BM 脂肪生成和骨转移。本综述检查了 IL-11 在病理学和骨组织中的作用、调节 IL-11 表达的细胞因子和途径，以及这些途径的反馈调节。
