相似文献
1
Redefining Neurodegenerative Treatment: Synergy of KEAP1, PROTACs, and Inflammatory Modulators.
ACS Med Chem Lett. 2024 Jan 29;15(2):167-168. doi: 10.1021/acsmedchemlett.4c00001. eCollection 2024 Feb 8.
2
The KEAP1-NRF2 System and Neurodegenerative Diseases.
Antioxid Redox Signal. 2023 May;38(13-15):974-988. doi: 10.1089/ars.2023.0234. Epub 2023 Mar 17.
3
Review of molecular mechanisms involved in the activation of the Nrf2-ARE signaling pathway by chemopreventive agents.
Methods Mol Biol. 2010;647:37-74. doi: 10.1007/978-1-60761-738-9_3.
4
A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.
Mol Cell Biol. 2010 Jul;30(13):3275-85. doi: 10.1128/MCB.00248-10. Epub 2010 Apr 26.
5
Keap1 degradation by autophagy for the maintenance of redox homeostasis.
Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13561-6. doi: 10.1073/pnas.1121572109. Epub 2012 Aug 7.
6
The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway.
Mol Cell Biol. 2020 Jun 15;40(13). doi: 10.1128/MCB.00099-20.
7
The Keap1-Nrf2 pathway: promising therapeutic target to counteract ROS-mediated damage in cancers and neurodegenerative diseases.
Biophys Rev. 2017 Feb;9(1):41-56. doi: 10.1007/s12551-016-0244-4. Epub 2016 Dec 6.
8
Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2.
Mol Cell Biol. 2007 Sep;27(18):6334-49. doi: 10.1128/MCB.00630-07. Epub 2007 Jul 16.
9
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.
Mol Cell Biol. 2004 Aug;24(16):7130-9. doi: 10.1128/MCB.24.16.7130-7139.2004.
10
The KEAP1-NRF2 system and neurodegenerative diseases.
Antioxid Redox Signal. 2023 Feb 3. doi: 10.1089/ars.2023.0005.
引用本文的文献
1
Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis.
Acta Pharm Sin B. 2025 Aug;15(8):4137-4155. doi: 10.1016/j.apsb.2025.05.025. Epub 2025 May 27.
2
Advances in KEAP1-based PROTACs as emerging therapeutic modalities: Structural basis and progress.
Redox Biol. 2025 Jul 21;85:103781. doi: 10.1016/j.redox.2025.103781.
3
Polygonatum polysaccharides as gut microbiota modulators: implications for autophagy-dependent PD-L1 clearance in cancer immunotherapy.
Front Nutr. 2025 Jun 24;12:1612644. doi: 10.3389/fnut.2025.1612644. eCollection 2025.
本文引用的文献
1
Redox regulation of the NLRP3-mediated inflammation and pyroptosis.
Biomed Khim. 2023 Dec;69(6):333-352. doi: 10.18097/PBMC20236906333.
2
Super-enhancers and the super-enhancer reader BRD4: tumorigenic factors and therapeutic targets.
Cell Death Discov. 2023 Dec 22;9(1):470. doi: 10.1038/s41420-023-01775-6.
3
Recent progress and applications of small molecule inhibitors of Keap1-Nrf2 axis for neurodegenerative diseases.
Eur J Med Chem. 2024 Jan 15;264:115998. doi: 10.1016/j.ejmech.2023.115998. Epub 2023 Nov 29.
4
Metabolite itaconate in host immunoregulation and defense.
Cell Mol Biol Lett. 2023 Dec 2;28(1):100. doi: 10.1186/s11658-023-00503-3.
5
Metal profiling in coronary ischemia-reperfusion injury: Implications for KEAP1/NRF2 regulated redox signaling.
Free Radic Biol Med. 2024 Jan;210:158-171. doi: 10.1016/j.freeradbiomed.2023.11.013. Epub 2023 Nov 19.
6
Reductive stress in cancer: coming out of the shadows.
Trends Cancer. 2024 Feb;10(2):103-112. doi: 10.1016/j.trecan.2023.10.002. Epub 2023 Nov 2.
Zotero 插件