The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Front Immunol. 2024 Jan 29;15:1309583. doi: 10.3389/fimmu.2024.1309583. eCollection 2024.
Pain is a common symptom in multiple sclerosis (MS), especially neuropathic pain, which has a significant impact on patients' mental and physical health and quality of life. However, risk factors that related to neuropathic pain, still remain unclear.
The study aimed to explore the risk factors of neuropathic pain among MS patients.
This retrospective study examined the consecutive patients diagnosed with MS in the Department of Neurology of Guangdong Provincial Hospital of Chinese Medicine between August 2011 and October 2022. Neuropathic pain was defined as "pain arising as a direct consequence of a lesion or disease affecting the somatosensory system". Demographic and clinical features were obtained from the electronic system of the hospital.
Our cohort revealed that the prevalence of patients with neuropathic pain in MS was 34.1%. The results indicated that the longer the spinal lesions, the greater the neuropathic pain risks (2-4: OR, 13.3(2.1-82), >5: OR, 15.2(2.7-86.8), p for tread: 0.037). Meanwhile, multivariate regression analysis showed that cervical and thoracic lesions (OR 4.276, 95% CI 1.366-13.382, P = 0.013), upper thoracic lesions (T1-T6) (OR 3.047, 95% CI 1.018-9.124, P = 0.046) were positively correlated with neuropathic pain, while basal ganglia lesions (OR 0.188, 95% CI 0.044-0.809, P = 0.025) were negatively correlated with neuropathic pain among MS patients.
Extended spinal lesions (≥3 spinal lesions), cervical and thoracic lesions, upper thoracic lesions were independent risk factors of neuropathic pain among MS patients. Furthermore, our study found that the longer the spinal lesions, the greater the neuropathic pain risks.
疼痛是多发性硬化症（MS）的常见症状，尤其是神经病理性疼痛，它对患者的身心健康和生活质量有重大影响。然而，与神经病理性疼痛相关的风险因素仍不清楚。
本研究旨在探讨 MS 患者神经病理性疼痛的危险因素。
本回顾性研究纳入了 2011 年 8 月至 2022 年 10 月期间在广东省中医院神经内科连续诊断为 MS 的患者。神经病理性疼痛定义为“直接由影响躯体感觉系统的病变或疾病引起的疼痛”。从医院的电子系统中获取人口统计学和临床特征。
我们的队列研究显示，MS 患者神经病理性疼痛的患病率为 34.1%。结果表明，脊髓病变越长，神经病理性疼痛的风险越大（2-4 个：OR，13.3（2.1-82）；>5 个：OR，15.2（2.7-86.8），p 趋势=0.037）。同时，多变量回归分析显示，颈椎和胸椎病变（OR 4.276，95%CI 1.366-13.382，P=0.013）、上胸椎病变（T1-T6）（OR 3.047，95%CI 1.018-9.124，P=0.046）与神经病理性疼痛呈正相关，而基底节病变（OR 0.188，95%CI 0.044-0.809，P=0.025）与 MS 患者的神经病理性疼痛呈负相关。
脊髓病变延长（≥3 个脊髓病变）、颈椎和胸椎病变、上胸椎病变是 MS 患者神经病理性疼痛的独立危险因素。此外，我们的研究发现，脊髓病变越长，神经病理性疼痛的风险越大。
