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分析选定的蛋白质标志物作为营养状态和炎症标志物对剖腹术后膈膨出发生的影响。

Analysis of the influence of selected protein markers as markers of nutritional status and inflammation on the occurrence of eventration after laparotomy.

机构信息

Department of Thoracic, General and Oncological Surgery, University Clinical Hospital of the Military Medical Academy, Central Veterans Hospital, Lodz, Poland.

出版信息

Pol Przegl Chir. 2023 Oct 12;96(1):42-48. doi: 10.5604/01.3001.0053.9183.

Abstract

<b><br>Introduction:</b> Eventration is a fairly rare complication after laparotomy, which consists of postoperative wound dehiscence and protrusion of the viscera outside the abdominal cavity. This complication is associated with a higher mortality rate. The known risk factors for this condition include malnutrition and the coexistence of inflammation or cancer.</br> <b><br>Aim:</b> The main aim of the study was to investigate the relationship between the occurrence of eventration after laparotomy and the patient's nutritional status with the intensity of inflammatory processes, expressed using selected protein markers.</br> <b><br>Material and method:</b> The study was based on the analysis of patients treated at our own center from January 2014 to December 2020. It included a group of patients who underwent laparotomy and who experienced eventration, as well as a control group of patients who underwent laparotomy but did not experience eventration after the procedure.</br> <b><br>Results:</b> The analysis showed that a lower serum albumin concentration is associated with a greater risk of eventration in patients who have undergone laparotomy due to acute abdominal disease. The study group and the control group differed significantly in the levels of: Hgb, serum total protein, CRP, lymphocytes, albumin, PCT, NRS.</br&gt.

摘要

<b><br>引言:</b>术后膈肌膨出是腹部手术后一种较为罕见的并发症,其特点为腹部切口裂开,内脏组织经裂开的切口疝出至腹腔外。这种并发症与较高的死亡率相关。已知这种情况的危险因素包括营养不良和炎症或癌症的并存。</br> <b><br>目的:</b>本研究的主要目的是研究术后膈肌膨出的发生与患者的营养状况与炎症过程强度之间的关系,通过使用选定的蛋白质标志物来表达。</br> <b><br>材料和方法:</b>本研究基于对 2014 年 1 月至 2020 年 12 月在我们中心治疗的患者进行分析。研究组包括因急性腹部疾病而行剖腹术并发生膈肌膨出的患者,以及对照组为因急性腹部疾病而行剖腹术但术后未发生膈肌膨出的患者。</br> <b><br>结果:</b>分析表明,血清白蛋白浓度较低与因急性腹部疾病而行剖腹术的患者发生膈肌膨出的风险增加相关。研究组和对照组在 Hgb、血清总蛋白、CRP、淋巴细胞、白蛋白、PCT、NRS 方面存在显著差异。</br>

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