Qian Jiahui, Zhang Yu, Zhao Weining, Hu Peng
Institute of Green Chemistry and Molecular Engineering, GBRCE for Functional Molecular Engineering, Lehn Institute of Functional Materials, School of Chemistry, Sun Yat-Sen University, Guangzhou 510006, China.
College of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China.
Chem Commun (Camb). 2024 Mar 5;60(20):2764-2767. doi: 10.1039/d3cc06149c.
In this article, we report a general protocol for the direct decarboxylative chlorination, iodination, and bromination of aliphatic carboxylic acids catalyzed by iron salts under visible light. This method enjoys a broad substrate scope with good functional group compatibility, including complex natural products. Benzylic and allylic C(sp)-H bonds can be retained under the oxidative halogenation conditions. This method also shows application potential for late-stage functionalization.
在本文中，我们报道了一种在可见光下铁盐催化脂肪族羧酸直接脱羧氯化、碘化和溴化的通用方法。该方法具有广泛的底物范围和良好的官能团兼容性，包括复杂的天然产物。苄基和烯丙基C(sp)-H键在氧化卤化条件下可以保留。该方法在后期官能团化方面也显示出应用潜力。
