铁盐在可见光下催化脂肪族羧酸的脱羧卤化反应。
Decarboxylative halogenation of aliphatic carboxylic acids catalyzed by iron salts under visible light.
作者信息
Qian Jiahui, Zhang Yu, Zhao Weining, Hu Peng
机构信息
Institute of Green Chemistry and Molecular Engineering, GBRCE for Functional Molecular Engineering, Lehn Institute of Functional Materials, School of Chemistry, Sun Yat-Sen University, Guangzhou 510006, China.
College of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China.
出版信息
Chem Commun (Camb). 2024 Mar 5;60(20):2764-2767. doi: 10.1039/d3cc06149c.
In this article, we report a general protocol for the direct decarboxylative chlorination, iodination, and bromination of aliphatic carboxylic acids catalyzed by iron salts under visible light. This method enjoys a broad substrate scope with good functional group compatibility, including complex natural products. Benzylic and allylic C(sp)-H bonds can be retained under the oxidative halogenation conditions. This method also shows application potential for late-stage functionalization.
在本文中，我们报道了一种在可见光下铁盐催化脂肪族羧酸直接脱羧氯化、碘化和溴化的通用方法。该方法具有广泛的底物范围和良好的官能团兼容性，包括复杂的天然产物。苄基和烯丙基C(sp)-H键在氧化卤化条件下可以保留。该方法在后期官能团化方面也显示出应用潜力。
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