Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada.
Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada.
CNS Drugs. 2024 Feb;38(2):77-91. doi: 10.1007/s40263-024-01061-8. Epub 2024 Feb 14.
Chronic pain complicates many diseases and is notoriously difficult to treat. In search of new therapeutic targets, pannexin-1 (Panx1) channels have sparked intense interest as a key mechanism involved in a variety of chronic pain conditions. Panx1 channels are transmembrane proteins that release ions and small molecules, such as adenosine triphosphate (ATP). They are expressed along important nodes of the pain pathway, modulating activity of diverse cell types implicated in the development and progression of chronic pain caused by injury or pathology. This review highlights advances that have unlocked the core structure and machinery controlling Panx1 function with a focus on understanding and treating chronic pain.
慢性疼痛使许多疾病变得复杂，且其治疗极具挑战性。在寻找新的治疗靶点的过程中，连接蛋白-1（Panx1）通道作为一种涉及多种慢性疼痛疾病的关键机制，引起了极大的关注。Panx1 通道是一种跨膜蛋白，可释放离子和小分子，如三磷酸腺苷（ATP）。它们沿疼痛途径的重要节点表达，调节多种细胞类型的活性，这些细胞类型与损伤或病理引起的慢性疼痛的发展和进展有关。这篇综述强调了在理解和治疗慢性疼痛方面，解锁控制 Panx1 功能的核心结构和机制方面的进展。
