DAMs 的多样性、命运和记忆。
The diversity, destiny, and memory of DAMs.
机构信息
Brain Immunology and Glia Center, University of Virginia, Charlottesville, VA, USA; Department of Neuroscience, University of Virginia, Charlottesville, VA, USA.
Brain Immunology and Glia Center, University of Virginia, Charlottesville, VA, USA; Department of Neuroscience, University of Virginia, Charlottesville, VA, USA; Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, USA.
出版信息
Immunity. 2024 Feb 13;57(2):200-202. doi: 10.1016/j.immuni.2024.01.004.
Disease-associated microglia (DAMs) are a unique microglial state in development and various CNS pathologies. In this issue of Immunity, Lan and colleagues provide novel insights into the diversity of DAMs in CNS diseases, revealing their terminal fate following juvenile stroke verses their reversible fate following neonatal stroke and their ability to maintain immune memory upon return to homeostatic states.
疾病相关小胶质细胞（DAMs）是一种在发育和各种中枢神经系统疾病中独特的小胶质细胞状态。在本期《免疫》中，Lan 及其同事提供了有关中枢神经系统疾病中 DAM 多样性的新见解，揭示了它们在幼年卒中后的终末命运、在新生儿卒中后的可逆命运，以及它们在回到稳态时维持免疫记忆的能力。
Zotero 插件