Geyer M A, Butcher R E, Fite K
Neurobehav Toxicol Teratol. 1985 Nov-Dec;7(6):759-65.
The permanence of developmental abnormalities from prenatal methylmercuric chloride (MMC) was examined in the offspring of Sprague-Dawley rats exposed on Days 6-15 of gestation to 0.00, 0.25, 1.25, 2.50, or 5.0 mg/kg MMC. The effects of MMC on reproduction and early physical development were examined together with tests of negative geotaxis, righting, pivoting, swimming, locomotor activity in an open field, and startle responses to either tactile or acoustic stimuli. No live offspring were produced by females treated with 5.0 mg/kg MMC. Offspring from the 2.50 mg/kg dose group displayed impaired performance on almost all pre-weaning measures and continuing abnormalities on longitudinal tests of locomotor activity in an open field and startle response performance.
研究了妊娠第6至15天暴露于0.00、0.25、1.25、2.50或5.0mg/kg甲基汞（MMC）的Sprague-Dawley大鼠后代中，产前甲基汞氯化物（MMC）导致的发育异常的持久性。研究了MMC对生殖和早期身体发育的影响，并进行了负趋地性、翻正、旋转、游泳、旷场运动活动以及对触觉或听觉刺激的惊吓反应测试。接受5.0mg/kg MMC处理的雌性大鼠未产生活的后代。2.50mg/kg剂量组的后代在几乎所有断奶前指标上表现受损，并且在旷场运动活动和惊吓反应性能的纵向测试中持续存在异常。
