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东莨菪碱与幻觉的感觉性条件作用

Scopolamine and the sensory conditioning of hallucinations.

作者信息

Warburton D M, Wesnes K, Edwards J, Larrad D

出版信息

Neuropsychobiology. 1985;14(4):198-202. doi: 10.1159/000118227.

DOI:10.1159/000118227
PMID:3835496
Abstract

By means of a sensory conditioning procedure, auditory 'hallucinations' were produced in a set of subjects by pairing a light and a tone. The effect of two doses of scopolamine on the occurrence of these hallucinations was investigated, and the results showed that they were more likely to occur after scopolamine than when subjects had received a placebo. This change was attributed to the impairment of information processing induced by scopolamine.

摘要

通过一种感觉条件作用程序,通过将光和音调配对,在一组受试者中产生了听觉“幻觉”。研究了两剂东莨菪碱对这些幻觉发生的影响,结果表明,与接受安慰剂的受试者相比,服用东莨菪碱后幻觉更有可能发生。这种变化归因于东莨菪碱引起的信息处理受损。

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1
Scopolamine and the sensory conditioning of hallucinations.东莨菪碱与幻觉的感觉性条件作用
Neuropsychobiology. 1985;14(4):198-202. doi: 10.1159/000118227.
2
Some additional data on the effects of scopolamine on habituation and conditioning in answer to Dr. Barton Meyers.关于东莨菪碱对习惯化和条件作用影响的一些补充数据,以回应巴顿·迈尔斯博士。
Psychopharmacologia. 1968;13(4):356-8.
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Effects of scopolamine injection during CS-US interval on conditioning.在条件刺激-非条件刺激间隔期间注射东莨菪碱对条件作用的影响。
Psychol Rep. 1971 Jun;28(3):690. doi: 10.2466/pr0.1971.28.3.690.
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Scopolamine does not restore normal conditioned avoidance performance in raclopride-treated rats.东莨菪碱不能恢复用雷氯必利治疗的大鼠的正常条件性回避行为表现。
J Neural Transm (Vienna). 2001;108(4):415-30. doi: 10.1007/s007020170063.
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Towards an animal model of an antipsychotic drug-resistant cognitive impairment in schizophrenia: scopolamine induces abnormally persistent latent inhibition, which can be reversed by cognitive enhancers but not by antipsychotic drugs.迈向精神分裂症中抗精神病药物耐药性认知障碍的动物模型:东莨菪碱诱导异常持续的潜伏抑制,认知增强剂可逆转这种抑制,但抗精神病药物不能。
Int J Neuropsychopharmacol. 2009 Mar;12(2):227-41. doi: 10.1017/S1461145708009176. Epub 2008 Aug 8.
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Scopolamine and Pavlovian fear conditioning in rats: dose-effect analysis.东莨菪碱与大鼠的巴甫洛夫式恐惧条件反射:剂量效应分析。
Neuropsychopharmacology. 1999 Dec;21(6):731-44. doi: 10.1016/S0893-133X(99)00083-4.
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Scopolamine administered before and after training impairs both contextual and auditory-cue fear conditioning.在训练前后给予东莨菪碱会损害情境性和听觉线索恐惧条件反射。
Neurobiol Learn Mem. 1996 Jan;65(1):73-81. doi: 10.1006/nlme.1996.0008.
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Scopolamine induces disruption of latent inhibition which is prevented by antipsychotic drugs and an acetylcholinesterase inhibitor.东莨菪碱会导致潜伏抑制的破坏,而抗精神病药物和一种乙酰胆碱酯酶抑制剂可预防这种破坏。
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Effects of scopolamine and ketamine on reconsolidation of morphine conditioned place preference in rats.东莨菪碱和氯胺酮对大鼠吗啡条件性位置偏爱再巩固的影响。
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Blockade of muscarinic acetylcholine receptors in the ventral tegmental area disrupts food-related learning in rats.阻断腹侧被盖区的毒蕈碱型乙酰胆碱受体会破坏大鼠与食物相关的学习。
Psychopharmacology (Berl). 2006 Jan;184(1):87-94. doi: 10.1007/s00213-005-0235-9. Epub 2005 Nov 24.

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