Centro de Pesquisa e Desenvolvimento de Fármacos, Department of Morphology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Centro de Pesquisa e Desenvolvimento de Fármacos, Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Br J Pharmacol. 2024 Apr;181(7):917-937. doi: 10.1111/bph.16323. Epub 2024 Feb 14.
Inflammation is elicited by the host in response to microbes, and is believed to be essential for protection against infection. However, we have previously hypothesized that excessive or misplaced inflammation may be a major contributor to tissue dysfunction and death associated with viral and bacterial infections. The resolutive phase of inflammation is a necessary condition to achieve homeostasis after acute inflammation. It is possible that targeting inflammation resolution may be beneficial for the host during infection. In this review, we summarize the evidence demonstrating the expression, roles and effects of the best described pro-resolving molecules in the context of bacterial and viral infections. Pro-resolving molecules play a pivotal role in modulating a spectrum of pathways associated with tissue inflammation and damage during both viral and bacterial infections. These molecules offer a blend of anti-inflammatory, pro-resolving and sometimes anti-infective benefits, all the while circumventing the undesired and immune-suppressive unwanted effects associated with glucocorticoids. Whether these beneficial effects will translate into benefits to patients clearly deserve further investigation.
炎症是宿主对微生物的反应，被认为是对抗感染的必要条件。然而，我们之前假设，过度或错位的炎症可能是与病毒和细菌感染相关的组织功能障碍和死亡的主要原因。炎症的消退阶段是急性炎症后恢复体内平衡的必要条件。在感染期间，靶向炎症消退可能对宿主有益。在这篇综述中，我们总结了证明在细菌和病毒感染背景下表达、作用和最佳描述的促解决分子的证据。促解决分子在调节与病毒和细菌感染期间组织炎症和损伤相关的一系列途径方面发挥着关键作用。这些分子提供了抗炎、促解决，有时还具有抗感染的益处，同时避免了与糖皮质激素相关的不良和免疫抑制作用。这些有益效果是否会转化为对患者的益处，显然值得进一步研究。
