University Unit of Hygiene, Epidemiology and Public Health, University of Brescia, 25123 Brescia, Italy.
Neurology Unit, Department of Continuity of Care and Frailty, ASST Spedali Civili Hospital, Brescia, Italy; Department of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, Italy.
Vaccine. 2024 Mar 19;42(8):1863-1867. doi: 10.1016/j.vaccine.2024.02.003. Epub 2024 Feb 14.
We evaluated the impact of COVID-19 vaccination on disease outcome in hospitalized patients with SARS-CoV-2 infection with a prospective study. 745 vaccinated and 451 unvaccinated patients consecutively admitted to a COVID-19 Hospital from 1st September 2021 to 1st September 2022 were included. Compared with unvaccinated cases, vaccinated patients were older, had more comorbidities, but had a lower risk of O2 need (odds ratio, OR, 0.46; 95 % CI 0.32-0.65) by logistic regression analysis adjusted for age, sex, comorbidity and WHO COVID-19 Clinical Progression Scale at admission. The ORs for O2 need were 0.38 (0.24-0.61), 0.50 (0.30-0.83) and 0.57 (0.34-0.96) in patients vaccinated 14-120, 121-180 and > 180 days prior to hospitalization, respectively. An anti-spike Ig titer higher than 5000 U/ml was associated with a reduced risk of O2 need (OR 0.52; 95 % CI 0.30-0.92). This study shows that COVID-19 vaccination has a significant impact on COVID-19 outcomes in hospitalized patients.
我们通过一项前瞻性研究评估了 COVID-19 疫苗接种对住院 SARS-CoV-2 感染患者疾病结局的影响。该研究纳入了 2021 年 9 月 1 日至 2022 年 9 月 1 日期间连续收治于 COVID-19 医院的 745 名接种疫苗和 451 名未接种疫苗的患者。与未接种疫苗的病例相比，接种疫苗的患者年龄更大，合并症更多，但通过调整年龄、性别、合并症和入院时的世卫组织 COVID-19 临床进展量表后， logistic 回归分析显示，他们需要吸氧的风险较低（比值比，OR，0.46；95%CI，0.32-0.65）。在接种疫苗 14-120、121-180 和>180 天前住院的患者中，需要吸氧的 OR 分别为 0.38（0.24-0.61）、0.50（0.30-0.83）和 0.57（0.34-0.96）。抗刺突 IgG 滴度高于 5000 U/ml 与降低需要吸氧的风险相关（OR 0.52；95%CI，0.30-0.92）。这项研究表明，COVID-19 疫苗接种对住院患者的 COVID-19 结局有显著影响。
