Department of Genetic Engineering, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, 603203, Tamil Nadu, India.
Department of Biotechnology, GITAM School of Science, GITAM (Deemed to be) University, Visakhapatnam, 530045, Andhra Pradesh, India.
Cell Biochem Biophys. 2024 Jun;82(2):399-409. doi: 10.1007/s12013-024-01227-7. Epub 2024 Feb 15.
Most cancers are not detected until they have progressed to the point of becoming malignant and life-threatening. Chemotherapy and conventional medicines are often ineffective against cancer. Although we have made significant progress, new conceptual discoveries are still required to investigate new treatments. The role of metastasis suppressor genes as a therapeutic option for limiting tumor progression and metastasis has been on the anvil for some time. In this review, we discuss the role of ITIH5 as a metastasis suppressor gene and catalog its involvement in different cancers. We further shed light on the mode of action of ITIH5 based on the available data. The review will provide a new perspective on ITIH5 as an anti-metastatic protein and hopefully serve as an impetus for future studies towards the application of ITIH5 for clinical intervention in targeting metastatic cancers.
大多数癌症直到发展到恶性和危及生命的阶段才被发现。化疗和传统药物通常对癌症无效。尽管我们已经取得了重大进展，但仍需要新的概念性发现来研究新的治疗方法。转移抑制基因作为限制肿瘤进展和转移的治疗选择的作用已经有一段时间了。在这篇综述中，我们讨论了 ITIH5 作为转移抑制基因的作用，并列出了它在不同癌症中的参与情况。我们进一步根据现有数据阐明了 ITIH5 的作用模式。该综述将为 ITIH5 作为一种抗转移蛋白提供新的视角，并有望为未来的研究提供动力，将 ITIH5 应用于临床干预转移性癌症的靶向治疗。
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