School of Life Science, Beijing Institute of Technology, No. 5, Zhongguancun South Street, Beijing, 100081, China.
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Chemical Biology Center, Peking University, Beijing, 100191, China.
ChemMedChem. 2024 May 17;19(10):e202300647. doi: 10.1002/cmdc.202300647. Epub 2024 Mar 4.
Nanodelivery systems (NDSs) provide promising prospects for decreasing drug doses, reducing side effects, and improving therapeutic effects. However, the bioapplications of NDSs are still compromised by their fast clearance, indiscriminate biodistribution, and limited tumor accumulation. Hence, engineering modification of NDSs aiming at promoting tumor-specific therapy and avoiding systemic toxicity is usually needed. An NDS integrating various functionalities, including flexible camouflage, specific biorecognition, and sensitive stimuli-responsiveness, into one sequence would be "smart" and highly effective. Herein, we systematically summarize the related principles, methods, and progress. At the end of the review, we predict the obstacles to precise nanoengineering and prospects for the future application of NDSs.
纳米递药系统（NDSs）为降低药物剂量、减少副作用和提高治疗效果提供了有前景的策略。然而，由于其快速清除、非选择性生物分布和有限的肿瘤积累，NDSs 的生物应用仍然受到限制。因此，通常需要对 NDSs 进行工程修饰，以促进肿瘤特异性治疗和避免全身毒性。将各种功能（包括灵活的伪装、特异性生物识别和敏感的刺激响应性）集成到一个序列中的 NDS 将是“智能的”，并且非常有效。本文系统地总结了相关的原理、方法和进展。在综述的最后，我们预测了精确纳米工程的障碍和 NDSs 的未来应用前景。
