Geneş D, Pekkolay Z, Şimşek M, Saraçoğlu H, Turgut M, Tekeş S, Tuzcu A K
Department of Adult Endocrinology and Metabolism, Dicle University Faculty of Medicine, Diyarbakir, Turkey.
Medical Biology and Genetics, Dicle University Faculty of Medicine, Diyarbakir, Turkey.
Acta Endocrinol (Buchar). 2023 Jul-Sep;19(3):281-285. doi: 10.4183/aeb.2023.281. Epub 2024 Feb 1.
This study aimed to evaluate the utility of C-peptide levels in the differentiation of monogenic forms of diabetes from type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) in clinical practice.
A total of 104 patients aged >16 who visited the Dicle University's Faculty of Medicine between April 2011 and December 2020 and were diagnosed with monogenic diabetes by genetic analysis or with T1DM and T2DM were randomly selected for retrospective evaluation. The C-peptide levels of these patients at the time of diagnosis of diabetes were compared.
Of the 104 patients, 24 (23%) were diagnosed with maturity-onset diabetes of the young (MODY), 40 (38.5%) with T1DM, and 40 (38.5%) with T2DM. Median C-peptide levels (ng/mL) (interquartile range) were 1.78 (1.24-2.88) in MODY group, 0.86 (0.34-1.22) in T1DM group, and 2.38 (1.58-4.27) in T2DM group.
There was a difference in C-peptide levels between MODY and T1DM groups but not between MODY and T2DM groups. As per clinical evaluations, although C-peptide levels of patients with MODY are similar to those of patients with T2DM patients, the possibility of C-peptide levels being similar to those required for T1DM diagnosis should also be considered.
本研究旨在评估在临床实践中，C肽水平在区分单基因糖尿病与1型糖尿病（T1DM）和2型糖尿病（T2DM）方面的效用。
随机选取2011年4月至2020年12月期间就诊于迪克莱大学医学院且年龄大于16岁、经基因分析诊断为单基因糖尿病或T1DM和T2DM的104例患者进行回顾性评估。比较这些患者糖尿病诊断时的C肽水平。
104例患者中，24例（23%）被诊断为青年发病的成年型糖尿病（MODY），40例（38.5%）为T1DM，40例（38.5%）为T2DM。MODY组C肽水平中位数（ng/mL）（四分位间距）为1.78（1.24 - 2.88），T1DM组为0.86（0.34 - 1.22），T2DM组为2.38（1.58 - 4.27）。
MODY组与T1DM组C肽水平存在差异，但MODY组与T2DM组之间无差异。根据临床评估，尽管MODY患者的C肽水平与T2DM患者相似，但也应考虑C肽水平与T1DM诊断所需水平相似的可能性。
