Li Jiaxuan, Lu Yining, Zhao Xuelian
Department of Plastic Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Department of Orthopedic Surgery, the Third Hospital of Hebei Medical University, Shijiazhuang, China.
Front Med (Lausanne). 2024 Jan 31;11:1263714. doi: 10.3389/fmed.2024.1263714. eCollection 2024.
Previous studies have shown that the onset and progression of several immunoinflammatory dermatoses are closely related to specific immune-inflammatory responses. To further assess the causal relationship between 41 inflammatory cytokines and immunoinflammatory dermatoses, we used a Mendelian randomization method.
Mendelian two-sample randomization utilized inflammatory cytokines from a GWAS abstract containing 8,293 healthy participants as well as psoriasis (4,510 cases and 212,242 controls), atopic dermatitis (7,024 cases and 198,740 controls), and vitiligo (131 cases and 207,482 controls). The causal relationship between exposure and outcome was explored primarily using inverse variance weighting. In addition, multiple sensitivity analyses, including MR-Egger, weighted median, simple model, weighted model, and MR-PRESSO, were simultaneously applied to enhance the final results.
The results showed that in clinical practice, IL-4 and IL-1RA were suggestive indicators of atopic dermatitis risk (OR = 0.878, 95% CI = 0.78-0.99, = 0.036; OR = 0.902, 95% CI = 0.82-1.00, = 0.045). SCGF-b was a suggestive indicator of psoriasis risk (OR = 1.095, 95% CI = 1.01-1.18, = 0.023). IL-4 is a suggestive indicator of vitiligo risk (OR = 2.948, 95% CI = 1.28-6.79, = 0.011).
Our findings suggest that circulating inflammatory cytokines may play a crucial role in the pathogenesis of chronic skin inflammation. IL-4 and IL-1RA may have inhibitory roles in the risk of developing atopic dermatitis, while SCGF-b may have a promoting role in the risk of developing psoriasis. Furthermore, IL-4 may contribute to the risk of developing vitiligo. These results provide insights into further understanding the mechanisms of chronic skin inflammation and offer new targets and strategies for the prevention and treatment of related diseases.
既往研究表明，几种免疫炎症性皮肤病的发病和进展与特定的免疫炎症反应密切相关。为了进一步评估41种炎性细胞因子与免疫炎症性皮肤病之间的因果关系，我们采用了孟德尔随机化方法。
孟德尔双样本随机化利用了来自一项包含8293名健康参与者以及银屑病（4510例病例和212242名对照）、特应性皮炎（7024例病例和198740名对照）和白癜风（131例病例和207482名对照）的全基因组关联研究摘要中的炎性细胞因子。主要使用逆方差加权法探讨暴露与结局之间的因果关系。此外，同时应用了多种敏感性分析，包括MR-Egger、加权中位数、简单模型、加权模型和MR-PRESSO，以增强最终结果。
结果显示，在临床实践中，IL-4和IL-1RA是特应性皮炎风险的提示性指标（OR = 0.878，95%CI = 0.78 - 0.99，P = 0.036；OR = 0.902，95%CI = 0.82 - 1.00，P = 0.045）。SCGF-b是银屑病风险的提示性指标（OR = 1.095，95%CI = 1.01 - 1.18，P = 0.023）。IL-4是白癜风风险的提示性指标（OR = 2.948，95%CI = 1.28 - 6.79，P = 0.011）。
我们的研究结果表明，循环炎性细胞因子可能在慢性皮肤炎症的发病机制中起关键作用。IL-4和IL-1RA可能对特应性皮炎的发病风险具有抑制作用，而SCGF-b可能对银屑病的发病风险具有促进作用。此外，IL-4可能与白癜风的发病风险有关。这些结果为进一步理解慢性皮肤炎症的机制提供了见解，并为相关疾病的预防和治疗提供了新的靶点和策略。
