Nguyen-Thi Phuong-Trang, Vo Tuong Kha, Pham Thi Hong Trang, Nguyen Thuy Trang, Van Vo Giau
Faculty of Pharmacy, HUTECH University, Ho Chi Minh City, 700000 Vietnam.
Department of Sports Medicine, Faculty of Medicine, VNU University of Medicine and Pharmacy, Vietnam National University, Hanoi, 100000 Vietnam.
3 Biotech. 2024 Mar;14(3):68. doi: 10.1007/s13205-024-03925-8. Epub 2024 Feb 13.
Alzheimer's disease (AD) is an age-dependent neurodegenerative disorder which is associated with the accumulation of proteotoxic Aβ peptides, and pathologically characterized by the deposition of Aβ-enriched plaques and neurofibrillary tangles. Given the social and economic burden caused by the rising frequency of AD, there is an urgent need for the development of appropriate therapeutics. Natural compounds are gaining popularity as alternatives to synthetic drugs due to their neuroprotective properties and higher biocompatibility. While natural compound's therapeutic effects for AD have been recently investigated in numerous in vitro and in vivo studies, only few have developed to clinical trials. The present review aims to provide a brief overview of the therapeutic effects, new insights, and upcoming perspectives of the preclinical and clinical trials of flavonoids for the treatment of Alzheimer's disease.
阿尔茨海默病（AD）是一种与年龄相关的神经退行性疾病，与蛋白毒性Aβ肽的积累有关，其病理特征为富含Aβ的斑块沉积和神经原纤维缠结。鉴于AD发病率上升所带来的社会和经济负担，迫切需要开发合适的治疗方法。天然化合物因其神经保护特性和更高的生物相容性，作为合成药物的替代品正越来越受到欢迎。虽然最近在众多体外和体内研究中对天然化合物治疗AD的效果进行了研究，但只有少数进入了临床试验阶段。本综述旨在简要概述黄酮类化合物治疗阿尔茨海默病的临床前和临床试验的治疗效果、新见解及未来展望。
