Kadiiska M, Stancheva S, Stoytchev Ts
Acta Physiol Pharmacol Bulg. 1985;11(4):27-32.
In experiments on male Wistar albino rats was studied the effect of Co, Cd, Ni, Zn, Hg and Pb on the activity of rat liver and brain monoamine oxidase (MAO) using tyramine, serotonin and beta-phenylethylamine as substrates. It was established that ZnSO4 significantly increased the activity of liver MAO with all substrates studied, Co(NO3)2 increased it when tyramine and serotonin were used while NiSO4 increased MAO activity when serotonin was used as a substrate. All metals studied did not change MAO activity in the brain except for Co(NO3)2 which significantly increased the enzyme activity with tyramine as a substrate. The activity of liver MAO proved to be more susceptible to heavy metals after subchronic exposure than that in the whole brain.
在对雄性Wistar白化大鼠进行的实验中，以酪胺、血清素和β-苯乙胺为底物，研究了钴、镉、镍、锌、汞和铅对大鼠肝脏和大脑单胺氧化酶（MAO）活性的影响。结果表明，在所研究的所有底物中，硫酸锌显著提高了肝脏MAO的活性；当使用酪胺和血清素作为底物时，硝酸钴提高了肝脏MAO的活性；当使用血清素作为底物时，硫酸镍提高了MAO的活性。除硝酸钴以酪胺为底物时显著提高了酶活性外，所研究的所有金属均未改变大脑中的MAO活性。亚慢性暴露后，肝脏MAO的活性比全脑中的活性对重金属更敏感。
