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静脉性腿部溃疡与慢性心力衰竭的关联：一项孟德尔随机研究。

Association between venous leg ulcers and chronic heart failure: A Mendelian randomization study.

机构信息

Shunde Hospital, Guangzhou University of Chinese Medicine, Foshan, China.

Graduate School, Beijing University of Chinese Medicine, Beijing, China.

出版信息

Int Wound J. 2024 Feb;21(2):e14744. doi: 10.1111/iwj.14744.

DOI:10.1111/iwj.14744
PMID:38358070
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10867869/
Abstract

An association between venous leg ulcers (VLU) and chronic heart failure (CHF) has been suggested by observational research. This study used Mendelian randomization (MR) methods to look into any possible bidirectional causal links between VLU and CHF. The 'TwoSampleMR' R package was employed for MR analyses. The association of VLU and CHF was assessed via methods of inverse variance weighted (IVW), weighted mode, MR Egger and weighted median. Results of IVW suggested no association between VLU and CHF (β 0.008356; SE 0.01889; p = 0.6582). The weighted median estimator (β -0.005777; SE 0.02059, p = 0.7791), MR-Egger (β -0.08955; SE 0.04557; p = 0.07296) and weighted mode (β -0.01202; SE 0.02467; p = 0.6341) showed consistent results. Conversely, evidence indicating that the presence of CHF increased the risk of VLU was lacking. In conclusion, there is no bidirectional causal relationship between VLU and CHF. Further studies are required to validate the findings of this study.

摘要

静脉溃疡（VLU）和慢性心力衰竭（CHF）之间的关联已被观察性研究表明。本研究使用孟德尔随机化（MR）方法研究 VLU 和 CHF 之间是否存在任何可能的双向因果关系。MR 分析采用了“TwoSampleMR”R 包。通过逆方差加权（IVW）、加权中位数、MR Egger 和加权模式方法评估 VLU 和 CHF 之间的关联。IVW 的结果表明 VLU 和 CHF 之间没有关联（β 0.008356；SE 0.01889；p = 0.6582）。加权中位数估计值（β -0.005777；SE 0.02059，p = 0.7791）、MR-Egger（β -0.08955；SE 0.04557；p = 0.07296）和加权模式（β -0.01202；SE 0.02467；p = 0.6341）得出了一致的结果。相反，缺乏表明 CHF 存在会增加 VLU 风险的证据。总之，VLU 和 CHF 之间没有双向因果关系。需要进一步的研究来验证本研究的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46ed/10867869/35239719ce7e/IWJ-21-e14744-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46ed/10867869/61f333090122/IWJ-21-e14744-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46ed/10867869/88848d59dd53/IWJ-21-e14744-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46ed/10867869/e0aa5866b96e/IWJ-21-e14744-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46ed/10867869/859f245fd19e/IWJ-21-e14744-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46ed/10867869/5d870565df73/IWJ-21-e14744-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46ed/10867869/35239719ce7e/IWJ-21-e14744-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46ed/10867869/61f333090122/IWJ-21-e14744-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46ed/10867869/88848d59dd53/IWJ-21-e14744-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46ed/10867869/e0aa5866b96e/IWJ-21-e14744-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46ed/10867869/859f245fd19e/IWJ-21-e14744-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46ed/10867869/5d870565df73/IWJ-21-e14744-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46ed/10867869/35239719ce7e/IWJ-21-e14744-g001.jpg

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引用本文的文献

[1]
RETRACTION: Association Between Venous Leg Ulcers and Chronic Heart Failure: A Mendelian Randomization Study.

Int Wound J. 2025-4

[2]
Double Trouble: A Case of an Evolving Leg Ulcer in the Setting of Heart Failure.

Cureus. 2025-3-4

[3]
Causal Association of Chronic Venous Insufficiency and Cardiovascular Diseases: A Univariable and Multivariable Mendelian Randomization Study.

Rev Cardiovasc Med. 2024-10-8

本文引用的文献

[1]
Chronic venous insufficiency and venous leg ulcers: Aetiology, on the pathophysiology-based treatment.

Int Wound J. 2023-10-19

[2]
Association between cardiac conditions with venous leg ulcers in patients with chronic venous insufficiency.

Phlebology. 2023-5

[3]
How health literacy relates to venous leg ulcer healing: A scoping review.

PLoS One. 2023

[4]
Assessing How Social Exposures Are Integrated in Exposome Research: A Scoping Review.

Environ Health Perspect. 2022-11

[5]
The associations of dietary habits with health, well-being, and behavior in adolescents: A cluster analysis.

Child Care Health Dev. 2023-5

[6]
Association of Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability.

JAMA Neurol. 2022-7-1

[7]
The Effects of Tai Chi Exercise Among Adults With Chronic Heart Failure: An Overview of Systematic Review and Meta-Analysis.

Front Cardiovasc Med. 2021-3-18

[8]
A Critical Overview of Systematic Reviews of Shenfu Injection for Heart Failure.

Cardiovasc Ther. 2021

[9]
A Literature Review of Pharmacological Agents to Improve Venous Leg Ulcer Healing.

Wounds. 2020-7

[10]
The 2020 update of the CEAP classification system and reporting standards.

J Vasc Surg Venous Lymphat Disord. 2020-2-27

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