Department of Cardiothoracic and Vascular Surgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Department of Vascular Surgery, University Hospital Fundación Santa Fe de Bogotá, Universidad de Los Andes, Bogota, Colombia.
Phlebology. 2023 May;38(4):281-286. doi: 10.1177/02683555231162294. Epub 2023 Mar 7.
Venous leg ulcers (VLUs) are the final stage of chronic venous insufficiency. This study aims to characterize the association between cardiovascular diseases and VLU.
A multicentric case-control study analyzed 17,788 patients between 2015 and 2020. Cases were matched (1:2) by age and sex, and odds ratios (OR) were analyzed with conditional logistic regressions adjusted by risk factors.
The prevalence of VLU was 15.2%. 2390 cases were analyzed. Diseases found to be associated with VLU were atrial fibrillation (OR, 1.21; 95% CI: 1.03-1.42), pulmonary hypertension (OR, 1.45; 95% CI: 1.06-2.00), right heart failure (OR, 1.27; 95% CI: 1.13-1.43), peripheral artery disease (OR, 2.21; 95% CI: 1.90-2.56), and history of pulmonary embolism (OR, 1.45; 95% CI: 1.06-2.00).
Certain cardiovascular conditions showed an association with VLU. Further studies are warranted to evaluate the effect that treating concomitant cardiovascular diseases might exert on the natural history of venous leg ulcers.
静脉性腿部溃疡（venous leg ulcers，VLUs）是慢性静脉功能不全的终末阶段。本研究旨在探讨心血管疾病与 VLU 之间的关系。
一项多中心病例对照研究分析了 2015 年至 2020 年间的 17788 例患者。通过年龄和性别进行 1:2 配对，采用条件逻辑回归分析调整了危险因素后的比值比（odds ratio，OR）。
VLU 的患病率为 15.2%。共分析了 2390 例病例。发现与 VLU 相关的疾病有房颤（OR，1.21；95%CI：1.03-1.42）、肺动脉高压（OR，1.45；95%CI：1.06-2.00）、右心衰竭（OR，1.27；95%CI：1.13-1.43）、外周动脉疾病（OR，2.21；95%CI：1.90-2.56）和肺栓塞史（OR，1.45；95%CI：1.06-2.00）。
某些心血管疾病与 VLU 相关。需要进一步研究评估治疗伴发心血管疾病对静脉性腿部溃疡自然病程的影响。
