Söderberg O, Hellström S, Stenfors L E, Thore M
Auris Nasus Larynx. 1985;12 Suppl 1:S241-3. doi: 10.1016/s0385-8146(85)80163-2.
Cleavage of the soft palate will cause purulent otitis media bilaterally in 100% of experimental animals (the rat) within 2 weeks. In this model a tympanostomy tube was inserted unilaterally. At 2, 7, and 21 days after the surgery the middle ear status was mapped in the otomicroscope and microbiological samples collected from the middle ear cavities and the nasopharynx. All intact ears became infected and developed purulent otitis media. Most of the tubulated ears exhibited normal middle ear cavities and remained culture negative. The few ventilated ears which were infected, however, showed a lower bacterial count than the corresponding intact ear. Thus in this model the insertion of a tympanostomy tube prevents the purulent otitis media from occurring.
软腭裂开会导致100%的实验动物(大鼠)在2周内双侧发生化脓性中耳炎。在此模型中,单侧插入了鼓膜造孔管。术后2天、7天和21天,在耳显微镜下观察中耳状况,并从中耳腔和鼻咽部采集微生物样本。所有未插管的耳朵均被感染并发展为化脓性中耳炎。大多数插管耳朵的中耳腔正常,培养结果仍为阴性。然而,少数被感染的通气耳朵的细菌数量低于相应的未插管耳朵。因此,在此模型中,插入鼓膜造孔管可预防化脓性中耳炎的发生。