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[肺动脉血栓内膜剥脱术后再灌注肺水肿患者采用静脉-静脉体外膜肺氧合进行循环支持]

[Circulatory support with venovenous ECMO in a patient with reperfusion pulmonary edema after pulmonary artery thromboendarterectomy].

作者信息

Lazcano-Díaz Emmanuel A, Encarnación-Martínez Uriel, Gaytán-García Cristhian J, Manzur-Sandoval Daniel, González-Ruiz Francisco J, García-Cruz Edgar, Ramos-Enríquez Ángel, Santos-Martínez Luis E, Cota-Apodaca Luis A, Hernández-Mejía Benjamín I, Escamilla-Ríos Dania E, Rojas-Velasco Gustavo

机构信息

Servicio de Terapia Intensiva Cardiovascular, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México.

出版信息

Arch Cardiol Mex. 2024 Feb 15;94(4):361-365. doi: 10.24875/ACM.23000142.

DOI:10.24875/ACM.23000142
PMID:38359441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11259409/
Abstract

Chronic thromboembolic pulmonary hypertension (CTEPH) is a subtype of pulmonary hypertension characterized by the obstruction of pulmonary arteries secondary to chronic thromboembolism. Pulmonary thromboendarterectomy surgery (PTE) is the main treatment for patients with CTEPH, as it removes the chronic thrombi from the pulmonary arteries. Pulmonary reperfusion syndrome is a common complication of the surgery, which involves the development of pulmonary edema in the area where blood perfusion improves after the surgery. The incidence of this syndrome varies from 8 to 91% depending on the criteria used for diagnosis, and it is one of the most serious complications of pulmonary thromboendarterectomy. In such cases, circulatory support with extracorporeal membrane oxygenation (ECMO) has become a valuable therapeutic modality. We present the case of a 60-year-old woman with a history of acute pulmonary embolism due to deep vein thrombosis of the right pelvic limb who was diagnosed later with CTEPH who was admitted for scheduled surgical treatment involving bilateral PTE. However, during the immediate postoperative period, she developed cardiogenic shock and refractory hypoxemia secondary to pulmonary reperfusion syndrome following the surgical procedure. As a result, she required veno-venous ECMO circulatory support for 6 days, leading to resolution of the pulmonary condition and clinical improvement.

摘要

慢性血栓栓塞性肺动脉高压(CTEPH)是肺动脉高压的一种亚型,其特征是继发于慢性血栓栓塞的肺动脉阻塞。肺动脉血栓内膜剥脱术(PTE)是CTEPH患者的主要治疗方法,因为它能清除肺动脉中的慢性血栓。肺再灌注综合征是该手术的常见并发症,涉及术后血液灌注改善区域出现肺水肿。根据诊断标准,该综合征的发生率在8%至91%之间,是肺动脉血栓内膜剥脱术最严重的并发症之一。在这种情况下,体外膜肺氧合(ECMO)循环支持已成为一种有价值的治疗方式。我们报告一例60岁女性病例,该患者有右下肢深静脉血栓形成导致急性肺栓塞病史,后来被诊断为CTEPH,因计划进行双侧PTE手术入院。然而,术后即刻,她因手术后继发肺再灌注综合征出现心源性休克和难治性低氧血症。结果,她需要静脉 - 静脉ECMO循环支持6天,从而使肺部状况得到缓解且临床症状改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40df/11259409/739e11c3185d/10125AMEX243-ACM-94-361-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40df/11259409/739e11c3185d/10125AMEX243-ACM-94-361-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40df/11259409/739e11c3185d/10125AMEX243-ACM-94-361-g001.jpg

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本文引用的文献

1
Distribution of thrombus predicts severe reperfusion pulmonary edema after pulmonary endarterectomy.血栓分布预测肺血管成形术后严重再灌注性肺水肿。
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ERS statement on chronic thromboembolic pulmonary hypertension.ERS 关于慢性血栓栓塞性肺动脉高压的声明。
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Survival after pulmonary thromboendarterectomy: effect of residual pulmonary hypertension.肺动脉血栓内膜切除术的生存情况:残余肺动脉高压的影响。
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