癌症中的表观基因组编辑：潜在治疗选择的进展和挑战。
Epigenome editing in cancer: Advances and challenges for potential therapeutic options.
机构信息
Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, United States; Department of Molecular and Medical Genetics, School of Medicine, Oregon Health & Science University, Portland, OR, United States.
Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, United States; Biomedical Engineering Graduate Program, Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, OR, United States.
出版信息
Int Rev Cell Mol Biol. 2024;383:191-230. doi: 10.1016/bs.ircmb.2023.10.001. Epub 2023 Nov 21.
Cancers are diseases caused by genetic and non-genetic environmental factors. Epigenetic alterations, some attributed to non-genetic factors, can lead to cancer development. Epigenetic changes can occur in tumor suppressors or oncogenes, or they may contribute to global cell state changes, making cells abnormal. Recent advances in gene editing technology show potential for cancer treatment. Herein, we will discuss our current knowledge of epigenetic alterations occurring in cancer and epigenetic editing technologies that can be applied to developing therapeutic options.
癌症是由遗传和非遗传环境因素引起的疾病。表观遗传改变，其中一些归因于非遗传因素，可导致癌症的发生。表观遗传改变可发生在肿瘤抑制基因或癌基因中，也可能导致细胞整体状态的改变，使细胞异常。基因编辑技术的最新进展显示出在癌症治疗方面的应用潜力。本文将讨论我们目前对癌症中发生的表观遗传改变以及可应用于开发治疗选择的表观遗传编辑技术的认识。
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