Department of Biomedical Engineering, School of Medicine, Vietnam National University Ho Chi Minh City (VNU-HCM), Ho Chi Minh City, Vietnam; Research Center for Genetics and Reproductive Health (CGRH), School of Medicine, National University HCMC, Ho Chi Minh City, Vietnam.
Faculty of Applied Sciences, International School, Vietnam National University, Hanoi, Vietnam.
Prog Mol Biol Transl Sci. 2024;203:197-223. doi: 10.1016/bs.pmbts.2024.01.003. Epub 2024 Jan 25.
RNA therapeutics are a class of drugs that use RNA molecules to treat diseases, including cancer. RNA therapeutics work by targeting specific genes or proteins involved in the disease process, with the aim of blocking or altering their activity to ultimately halt or reverse the disease progression. The use of RNA therapeutics in cancer treatment has shown great potential, as they offer the ability to specifically target cancer cells while leaving healthy cells intact. This is in contrast to traditional chemotherapy and radiation treatments, which can damage healthy cells and cause unpleasant side effects. The field of RNA therapeutics is rapidly advancing, with several types of RNA molecules being developed for cancer treatment, including small interfering RNA, microRNA, mRNA, and RNA aptamers. Each type of RNA molecule has unique properties and mechanisms of action, allowing for targeted and personalized cancer treatments. In this chapter, we will explore the different types of RNA therapeutics used in cancer treatment, their mechanisms of action, and their potential applications in treating different types of cancer. We will also discuss the challenges and opportunities in the development and research of RNA therapeutics for cancer, as well as the future outlook for this promising field.
RNA 疗法是一类利用 RNA 分子治疗疾病的药物，包括癌症。RNA 疗法通过针对疾病过程中涉及的特定基因或蛋白质来发挥作用，旨在阻断或改变其活性，最终阻止或逆转疾病进展。在癌症治疗中使用 RNA 疗法显示出巨大的潜力，因为它们能够特异性地靶向癌细胞，同时使健康细胞保持完整。这与传统的化疗和放疗形成了对比，后者会损伤健康细胞并引起不良反应。RNA 疗法领域正在迅速发展，正在开发几种用于癌症治疗的 RNA 分子，包括小干扰 RNA、microRNA、mRNA 和 RNA 适体。每种类型的 RNA 分子都具有独特的性质和作用机制，允许针对特定类型的癌症进行靶向和个性化治疗。在本章中，我们将探讨用于癌症治疗的不同类型的 RNA 疗法、它们的作用机制以及它们在治疗不同类型癌症中的潜在应用。我们还将讨论 RNA 疗法在癌症开发和研究中的挑战和机遇，以及这一有前途领域的未来展望。
