Department of Pharmacy, First Affiliated Hospital of Harbin Medical University, Harbin, China.
The Key Laboratory of Cardiovascular Disease Acousto-Optic Electromagnetic Diagnosis and Treatment in Heilongjiang Province, First Affiliated Hospital of Harbin Medical University, Harbin, China.
Int J Cardiol. 2024 Apr 15;401:131858. doi: 10.1016/j.ijcard.2024.131858. Epub 2024 Feb 13.
Heart failure (HF) is a serious clinical syndrome and a serious development or advanced stage of various heart diseases. Aging is an independent factor that causes pathological damage in cardiomyopathy and participates in the occurrence of HF at the molecular level by affecting mechanisms such as telomere shortening and mitochondrial dysfunction. Epigenetic changes have a significant impact on the aging process, and there is increasing evidence that genetic and epigenetic changes are key features of aging and aging-related diseases. Epigenetic modifications can affect genetic information by changing the chromatin state without changing the DNA sequence. Most of the genetic loci that are highly associated with cardiovascular diseases (CVD) are located in non-coding regions of the genome; therefore, the epigenetic mechanism of CVD has attracted much attention. In this review, we focus on the molecular mechanisms of HF during aging and epigenetic modifications mediating aging-related HF, emphasizing that epigenetic mechanisms play an important role in the pathogenesis of aging-related CVD and can be used as potential diagnostic and prognostic biomarkers, as well as therapeutic targets.
心力衰竭（HF）是一种严重的临床综合征，也是各种心脏病严重发展或进入晚期的阶段。衰老是导致心肌病发生病理损伤的一个独立因素，通过影响端粒缩短和线粒体功能障碍等机制，在分子水平上参与 HF 的发生。表观遗传变化对衰老过程有重大影响，越来越多的证据表明，遗传和表观遗传变化是衰老和与衰老相关疾病的关键特征。表观遗传修饰可以通过改变染色质状态而不改变 DNA 序列来影响遗传信息。与心血管疾病（CVD）高度相关的大多数遗传位点都位于基因组的非编码区域；因此，CVD 的表观遗传机制引起了广泛关注。在这篇综述中，我们重点关注衰老过程中心力衰竭的分子机制和介导与衰老相关的 HF 的表观遗传修饰，强调表观遗传机制在与衰老相关的 CVD 的发病机制中起着重要作用，并可作为潜在的诊断和预后生物标志物以及治疗靶点。
