Department of Infectious Disease and Hepatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Department of Infectious Disease and Hepatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Nitric Oxide. 2024 Apr 1;145:41-48. doi: 10.1016/j.niox.2024.02.002. Epub 2024 Feb 13.
Hydrogen sulfide (HS) is the third new gas signaling molecule in the human body after the discovery of NO and CO. Similar to NO, it has the functions of vasodilation, anti-inflammatory, antioxidant, and regulation of cell formation. Enzymes that can produce endogenous HS, such as CSE, CSB, and 3-MST, are common in liver tissues and are important regulatory molecules in the liver. In the development of liver fibrosis, HS concentration and expression of related enzymes change significantly, which makes it possible to use exogenous gases to treat liver diseases. This review summarizes the role of HS in liver fibrosis and its complications induced by NAFLD and CCl, and elaborates on the anti-liver fibrosis effect of HS through the mechanism of reducing oxidative stress, inhibiting inflammation, regulating autophagy, regulating glucose and lipid metabolism, providing theoretical reference for further research on the treatment of liver fibrosis with HS.
硫化氢 (HS) 是继发现 NO 和 CO 之后人体中第三种新的气体信号分子。与 NO 类似，它具有血管舒张、抗炎、抗氧化和调节细胞形成的功能。能够产生内源性 HS 的酶，如 CSE、CSB 和 3-MST，在肝组织中很常见，是肝脏中的重要调节分子。在肝纤维化的发展过程中，HS 浓度和相关酶的表达发生显著变化，这使得使用外源性气体治疗肝脏疾病成为可能。本综述总结了 HS 在 NAFLD 和 CCl 诱导的肝纤维化及其并发症中的作用，并通过降低氧化应激、抑制炎症、调节自噬、调节糖脂代谢等机制阐述了 HS 的抗肝纤维化作用，为 HS 治疗肝纤维化的进一步研究提供了理论参考。
