Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Cell Signal. 2024 May;117:111099. doi: 10.1016/j.cellsig.2024.111099. Epub 2024 Feb 13.
Lipotoxicity arises from the accumulation of lipid intermediates in non-adipose tissue, precipitating cellular dysfunction and death. Ceramide, a toxic byproduct of excessive free fatty acids, has been widely recognized as a primary contributor to lipotoxicity, mediating various cellular processes such as apoptosis, differentiation, senescence, migration, and adhesion. As the hub of lipid metabolism, the excessive accumulation of ceramides inevitably imposes stress on the mitochondria, leading to the disruption of mitochondrial homeostasis, which is typified by adequate ATP production, regulated oxidative stress, an optimal quantity of mitochondria, and controlled mitochondrial quality. Consequently, this review aims to collate current knowledge and facts regarding the involvement of ceramides in mitochondrial energy metabolism and quality control, thereby providing insights for future research.
脂毒性是由于脂质中间产物在非脂肪组织中的积累而产生的，导致细胞功能障碍和死亡。神经酰胺是过量游离脂肪酸的有毒副产品，已被广泛认为是脂毒性的主要原因之一，它介导了各种细胞过程，如细胞凋亡、分化、衰老、迁移和黏附。作为脂质代谢的中心，神经酰胺的过度积累不可避免地给线粒体带来压力，导致线粒体稳态的破坏，其特征是足够的 ATP 产生、氧化应激的调节、适量的线粒体和受控的线粒体质量。因此，本综述旨在整理目前关于神经酰胺参与线粒体能量代谢和质量控制的知识和事实，为未来的研究提供思路。
